Liu Yangyun, Jiang Wen, Mao Kunhua, Chen Qiong
Department of Otolaryngology Head and Neck Surgery, No. 163 Hospital of PLA, Changsha 410003, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Apr;26(7):308-11.
To explore the best evaluating time of curative effect on sudden deafness so that the curative effect on sudden deafness can been evaluated more exactly and literally.
Pure tone audiometries in 112 cases of sudden deafness were performed on the pretreatment day and on the third, seventh, fourteenth post-treatment day, and in the first, second, third, fourth post-treatment month. All of acoustical data were analyzed.
The total effective rates were statistical different between the third, seventh post-treatment day and the fourteenth post-treatment day, the first, second, third, fourth post-treatment month. There were no statistical difference between the fourteenth post-treatment day and the first post-treatment month. There were statistical difference between the fourteenth post-treatment day and the second, third, fourth post-treatment month. The total effective rates were no statistical difference between the first and the second, third, fourth post-treatment month but it was fluctuated in the first post-treatment month. The total effective rates were no statistical difference between the second and the third, fourth post-treatment month and it was changeless on the second post-treatment month. From the curve of recruitment of hearing in different time, the curve of the total effective rates ascend from the third post-treatment day, then get to plateau from the second post-treatment month. If the cure rates, the efficiency rates, the effective rates in different time were analyzed, respectively, the hearing improvement ascend in first two weeks then. Hearing improvement get to plateau from fourteenth post-treatment day.
(1) The evaluated results of curative effect to sudden deafness correlated vary in different time point post-treatment. (2) Prognosis can be predicted approximately 2 weeks after treatment. Patients who recover acoustic sensibility within 2 weeks have more significant improvement than the patients who hearing improvement after 2 weeks treatment. (3) The results of curative effect are stable after 2 months. If the data of this time were adopted, it would be more objective and accurate to evaluate the curative effect on sudden deafness.
探讨突发性聋疗效的最佳评估时间，以便更准确、客观地评估突发性聋的疗效。
对112例突发性聋患者在治疗前及治疗后第3天、第7天、第14天，以及治疗后第1个月、第2个月、第3个月、第4个月进行纯音听力测试，并对所有听力数据进行分析。
治疗后第3天、第7天与第14天、治疗后第1个月、第2个月、第3个月、第4个月的总有效率有统计学差异；治疗后第14天与治疗后第1个月无统计学差异；治疗后第14天与治疗后第2个月、第3个月、第4个月有统计学差异；治疗后第1个月与第2个月、第3个月、第4个月的总有效率无统计学差异，但在治疗后第1个月有波动；治疗后第2个月与第3个月、第4个月的总有效率无统计学差异，且在治疗后第2个月稳定。从不同时间听力恢复曲线看，总有效率曲线从治疗后第3天开始上升，至治疗后第2个月达到平台期。若分别分析不同时间的治愈率、显效率、有效率，听力改善在前两周上升，从治疗后第14天开始达到平台期。
（1）突发性聋治疗后不同时间点疗效评估结果存在差异。（2）治疗后约2周可大致预测预后，2周内恢复听力者较2周后听力改善者预后更佳。（3）治疗2个月后疗效结果稳定，采用此时数据评估突发性聋疗效更客观准确。
