• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

接受异基因造血细胞移植治疗滤泡性淋巴瘤的多发性硬化症患者寡克隆带清除后的病情进展及脑脊液炎症

Progression and CSF Inflammation after Eradication of Oligoclonal Bands in an MS Patient Treated with Allogeneic Hematopoietic Cell Transplantation for Follicular Lymphoma.

作者信息

Braendstrup P, Langkilde A R, Schreiber K, Ravnborg M, Sellebjerg F, Vindeløv L

机构信息

Allogeneic Hematopoietic Cell Transplantation Laboratory, Department of Hematology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

出版信息

Case Rep Neurol. 2012 May;4(2):101-6. doi: 10.1159/000339738. Epub 2012 Jun 12.

DOI:10.1159/000339738
PMID:22740825
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3383234/
Abstract

BACKGROUND

Allogeneic hematopoietic cell transplantation (allo-HCT) has been proposed as treatment for multiple sclerosis (MS) and other autoimmune diseases.

AIMS

To describe the effects of allo-HCT on the course of MS in a 49-year-old woman with longstanding progressive MS who was treated with allo-HCT for follicular lymphoma.

METHODS

Non-myeloablative conditioning allo-HCT, examination for IgG oligoclonal bands and measurement of CXCL13 and matrix metalloproteinase-9 (MMP-9) concentration in the cerebrospinal fluid (CSF).

RESULTS

Despite the disappearance of oligoclonal bands in CSF, disease progression and CSF inflammation was observed.

CONCLUSIONS

We hypothesize that CXCL13 and MMP-9 detected in CSF may reflect ongoing, pathogenic immune activation even after the eradication of intrathecal IgG synthesis. This suggests that progressive MS may depend more on innate than on adaptive immune activation.

摘要

背景

异基因造血细胞移植（allo-HCT）已被提议用于治疗多发性硬化症（MS）和其他自身免疫性疾病。

目的

描述异基因造血细胞移植对一名49岁患有长期进展性MS的女性的病程影响，该女性因滤泡性淋巴瘤接受了异基因造血细胞移植治疗。

方法

非清髓性预处理异基因造血细胞移植、检测脑脊液中IgG寡克隆带以及测量脑脊液中CXCL13和基质金属蛋白酶-9（MMP-9）的浓度。

结果

尽管脑脊液中寡克隆带消失，但仍观察到疾病进展和脑脊液炎症。

结论

我们推测，即使鞘内IgG合成被消除，脑脊液中检测到的CXCL13和MMP-9可能反映持续的致病性免疫激活。这表明进展性MS可能更多地依赖先天性免疫激活而非适应性免疫激活。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4438/3383234/34a9d4428c41/crn-0004-0101-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4438/3383234/34a9d4428c41/crn-0004-0101-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4438/3383234/34a9d4428c41/crn-0004-0101-g01.jpg

相似文献

1
Progression and CSF Inflammation after Eradication of Oligoclonal Bands in an MS Patient Treated with Allogeneic Hematopoietic Cell Transplantation for Follicular Lymphoma.接受异基因造血细胞移植治疗滤泡性淋巴瘤的多发性硬化症患者寡克隆带清除后的病情进展及脑脊液炎症
Case Rep Neurol. 2012 May;4(2):101-6. doi: 10.1159/000339738. Epub 2012 Jun 12.
2
Bone-marrow transplantation fails to halt intrathecal lymphocyte activation in multiple sclerosis.骨髓移植无法阻止多发性硬化症患者鞘内淋巴细胞的激活。
J Neurol Neurosurg Psychiatry. 2008 Sep;79(9):1013-5. doi: 10.1136/jnnp.2007.133520. Epub 2008 Jan 25.
3
Cerebrospinal fluid CXCL13 in clinically isolated syndrome patients: Association with oligoclonal IgM bands and prediction of Multiple Sclerosis diagnosis.临床孤立综合征患者脑脊液中的CXCL13：与寡克隆IgM带的关联及对多发性硬化症诊断的预测
J Neuroimmunol. 2015 Jun 15;283:64-9. doi: 10.1016/j.jneuroim.2015.04.011. Epub 2015 Apr 25.
4
Increased cortical lesion load and intrathecal inflammation is associated with oligoclonal bands in multiple sclerosis patients: a combined CSF and MRI study.多发性硬化症患者皮质病变负荷增加和鞘内炎症与寡克隆带相关：脑脊液和磁共振成像联合研究
J Neuroinflammation. 2017 Feb 21;14(1):40. doi: 10.1186/s12974-017-0812-y.
5
Detection of oligoclonal free kappa chains in the absence of oligoclonal IgG in the CSF of patients with suspected multiple sclerosis.在疑似多发性硬化症患者的脑脊液中，在无寡克隆IgG的情况下检测寡克隆游离κ链。
J Neurol Neurosurg Psychiatry. 2004 Feb;75(2):308-10. doi: 10.1136/jnnp.2003.010710.
6
The complex relationship between oligoclonal bands, lymphocytes in the cerebrospinal fluid, and immunoglobulin G antibodies in multiple sclerosis: Indication of serum contribution.多发性硬化症中寡克隆带、脑脊液中的淋巴细胞与免疫球蛋白G抗体之间的复杂关系：血清贡献的指征
PLoS One. 2017 Oct 23;12(10):e0186842. doi: 10.1371/journal.pone.0186842. eCollection 2017.
7
The influence of disease duration, clinical course, and immunosuppressive therapy on the synthesis of intrathecal oligoclonal IgG bands in multiple sclerosis.多发性硬化症患者鞘内寡克隆 IgG 带合成与疾病持续时间、临床病程和免疫抑制治疗的关系。
J Neuroimmunol. 2013 Nov 15;264(1-2):100-5. doi: 10.1016/j.jneuroim.2013.09.003. Epub 2013 Sep 18.
8
Reibergram and oligoclonal bands in diagnosis of multiple sclerosis.赖伯图和寡克隆区带在多发性硬化症诊断中的应用
Med Arch. 2012;66(4):222-5. doi: 10.5455/medarh.2012.66.222-225.
9
Reduced-Intensity Allografting as First Transplantation Approach in Relapsed/Refractory Grades One and Two Follicular Lymphoma Provides Improved Outcomes in Long-Term Survivors.降低强度同种异体移植作为复发/难治性一、二级滤泡性淋巴瘤首次移植方法可改善长期幸存者的预后。
Biol Blood Marrow Transplant. 2015 Dec;21(12):2091-2099. doi: 10.1016/j.bbmt.2015.07.028. Epub 2015 Aug 4.
10
Oligoclonal restriction of antiviral immunoreaction in oligoclonal band-negative MS patients.寡克隆带阴性多发性硬化症患者抗病毒免疫反应的寡克隆限制
Acta Neurol Scand. 2015 Jun;131(6):381-8. doi: 10.1111/ane.12350. Epub 2014 Nov 17.

引用本文的文献

1
Intrathecal IgG synthesis: a resistant and valuable target for future multiple sclerosis treatments.鞘内IgG合成：未来多发性硬化症治疗中一个持久且有价值的靶点。
Mult Scler Int. 2015;2015:296184. doi: 10.1155/2015/296184. Epub 2015 Jan 8.

本文引用的文献

1
Allogeneic hematopoietic cell transplantation: the state of the art.异基因造血细胞移植：最新进展。
Expert Rev Hematol. 2010 Jun;3(3):285-99. doi: 10.1586/ehm.10.21.
2
Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS.活动性多发性硬化症患者脑脊液中趋化因子CXCL13浓度升高。
Neurology. 2009 Dec 8;73(23):2003-10. doi: 10.1212/WNL.0b013e3181c5b457.
3
The relation between inflammation and neurodegeneration in multiple sclerosis brains.多发性硬化症患者大脑中炎症与神经退行性变之间的关系。
Brain. 2009 May;132(Pt 5):1175-89. doi: 10.1093/brain/awp070. Epub 2009 Mar 31.
4
The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease?多发性硬化症的挑战：我们如何治愈一种慢性异质性疾病？
Ann Neurol. 2009 Mar;65(3):239-48. doi: 10.1002/ana.21640.
5
Continued disease activity in a patient with multiple sclerosis after allogeneic hematopoietic cell transplantation.异基因造血细胞移植后多发性硬化症患者疾病活动持续存在。
Arch Neurol. 2009 Jan;66(1):116-20. doi: 10.1001/archneurol.2008.522.
6
Multiple sclerosis.多发性硬化症
Lancet. 2008 Oct 25;372(9648):1502-17. doi: 10.1016/S0140-6736(08)61620-7.
7
Autologous and allogeneic hematopoietic stem cell transplantation for Multiple Sclerosis: perspective on mechanisms of action.自体和异体造血干细胞移植治疗多发性硬化症：作用机制的观点
J Neuroimmunol. 2008 Jul 15;197(2):89-98. doi: 10.1016/j.jneuroim.2008.04.030. Epub 2008 Jun 9.
8
Failure of allogeneic bone marrow transplantation to arrest disease activity in multiple sclerosis.异基因骨髓移植未能阻止多发性硬化症的疾病活动。
Mult Scler. 2007 Sep;13(8):1071-5. doi: 10.1177/1352458507076981. Epub 2007 Jul 10.
9
Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology.继发进展型多发性硬化中的脑膜B细胞滤泡与疾病的早期发作和严重的皮质病理相关。
Brain. 2007 Apr;130(Pt 4):1089-104. doi: 10.1093/brain/awm038.
10
Autologous haematopoietic stem cell transplantation fails to stop demyelination and neurodegeneration in multiple sclerosis.
Brain. 2007 May;130(Pt 5):1254-62. doi: 10.1093/brain/awl370. Epub 2007 Feb 9.