接受239钚治疗的髓系白血病小鼠。
Myeloid leukemia 239Pu-treated mice.
作者信息
Svoboda V, Bubeníková D, Kotasková Z
出版信息
J Cancer Res Clin Oncol. 1981;100(3):255-62. doi: 10.1007/BF00410686.
Incidence of myeloid leukemia was studied in 79 mice injected i.v. with 180 kBq 239Pu/kg. Plutonium-treated mice were compared with 70 controls of the same origin and sex (random-bred ICR-SPF female mice). The animals were killed moribund and the disease was diagnosed on the basis of histological and cytologic examination of bone marrow, spleen, liver, peripheral blood, and other tissues. It has been found that 22 plutonium-treated mice (27.8%) and 17 controls (24.3%) were leukemic. The mean survival of diseased animals was 459 +/- 19 days in the tested group and 559 +/- 24 days in controls. It means that the occurrence of myeloid leukemia was not very different in irradiated and control mice, but under plutonium contamination the disease appeared significantly earlier and its incidence was shifted to the younger age.
对79只经静脉注射180 kBq 239Pu/kg的小鼠进行了髓系白血病发病率的研究。将接受钚处理的小鼠与70只相同来源和性别的对照小鼠（随机繁殖的ICR-SPF雌性小鼠）进行比较。动物在濒死时处死，并根据对骨髓、脾脏、肝脏、外周血和其他组织的组织学和细胞学检查诊断疾病。结果发现，22只接受钚处理的小鼠（27.8%）和17只对照小鼠（24.3%）患有白血病。患病动物的平均存活时间在测试组中为459±19天，在对照组中为559±24天。这意味着照射小鼠和对照小鼠中髓系白血病的发生率没有很大差异，但在钚污染情况下，疾病出现得明显更早，且发病率向更年轻的年龄转移。
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