Hwang Mark, Farasatpour Mishel, Williams Campbell D, Margenthaler Julie A, Virgo Katherine S, Johnson Frank E
Department of Surgery, Saint Louis University Hospital, St. Louis, MO 63110, USA.
Oncol Lett. 2012 Apr 1;3(4):845-850. doi: 10.3892/ol.2012.560. Epub 2012 Jan 9.
The outcomes of treatment of physical illnesses are strongly affected by the presence of schizophrenia. We aimed to quantify the clinical course of schizophrenic breast cancer patients who were eligible for adjuvant chemotherapy to determine whether patients with this mental illness receive appropriate treatment for this physical illness. We searched the national Department of Veterans Affairs (DVA) computer database using computer codes for schizophrenia to identify patients who later developed breast cancer and were treated in DVA medical centers. Computer-based data were supplemented with chart-based clinical indicators. There were 55 subjects who appeared to be appropriate candidates for adjuvant systemic therapy. A number of these candidates were not offered postoperative endocrine or cytotoxic chemotherapy, while others refused treatment or were non-compliant. Behaviors typical of schizophrenic subjects, including hostility to caregivers, often disrupt their care. Schizophrenic patients often have advanced-stage cancer at diagnosis, often delay diagnosis and are frequently hostile towards healthcare workers. Many of these patients refuse therapy and/or are non-compliant.
躯体疾病的治疗结果受到精神分裂症的显著影响。我们旨在量化符合辅助化疗条件的精神分裂症乳腺癌患者的临床病程，以确定患有这种精神疾病的患者是否针对这种躯体疾病接受了适当的治疗。我们使用精神分裂症的计算机编码在国家退伍军人事务部（DVA）计算机数据库中进行搜索，以识别后来患乳腺癌并在DVA医疗中心接受治疗的患者。基于计算机的数据辅以基于病历的临床指标。有55名受试者似乎是辅助全身治疗的合适人选。其中一些候选人未接受术后内分泌或细胞毒性化疗，而其他人拒绝治疗或不配合治疗。精神分裂症患者典型的行为，包括对护理人员的敌意，常常扰乱他们的护理。精神分裂症患者在诊断时往往患有晚期癌症，常常延迟诊断，并且经常对医护人员怀有敌意。这些患者中的许多人拒绝治疗和/或不配合治疗。
