Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, USA.
Am J Clin Nutr. 2012 Aug;96(2):269-74. doi: 10.3945/ajcn.112.037960. Epub 2012 Jun 27.
Few studies have evaluated the association between the n-3 fatty acid α-linolenic acid (ALA) and the incidence of congestive heart failure (CHF).
We investigated whether plasma phospholipid concentrations and estimated dietary consumption of ALA are associated with incident CHF.
We used data from the Cardiovascular Health Study, a prospective cohort study of cardiovascular diseases among adults aged ≥65 y, from 4 US communities. A total of 2957 participants free of prevalent heart disease and with available fatty acid measurements were included in biomarker analyses (30,722 person-years and 686 incident CHF events). A total of 4432 participants free of prevalent heart disease were included in dietary analyses (52,609 person-years and 1072 events). We investigated the association of ALA with incident CHF by using Cox regression.
After adjustment for age, sex, race, education, smoking status, BMI, waist circumference, and alcohol consumption, plasma phospholipid ALA was not associated with incident CHF (HR for the highest compared with the lowest quartile: 0.97; 95% CI: 0.79, 1.21; P-trend = 0.85). Likewise, dietary ALA was not associated with incident CHF (adjusted HR for the highest compared with the lowest quartile: 0.96; 95% CI: 0.82, 1.20; P-trend = 0.97). We observed no association of biomarker or dietary ALA with nonvalvular CHF subtype. We also found little evidence of an association between ALA and CHF in subgroups based on age, sex, diabetes, fish consumption, BMI, or FADS2 genotype (rs1535).
ALA intake is not associated with incident CHF in older adults. This trial was registered at clinicaltrials.gov as NCT00005133.
很少有研究评估 n-3 脂肪酸 α-亚麻酸（ALA）与充血性心力衰竭（CHF）发生率之间的关系。
我们研究了血浆磷脂酰胆碱中 ALA 的浓度和估计的 ALA 饮食摄入量是否与 CHF 的发生有关。
我们使用了心血管健康研究的数据，这是一项针对 4 个美国社区≥65 岁成年人的心血管疾病前瞻性队列研究。共有 2957 名无现有心脏病且可进行脂肪酸测量的参与者被纳入生物标志物分析（30722 人年和 686 例 CHF 事件）。共有 4432 名无现有心脏病的参与者被纳入饮食分析（52609 人年和 1072 例事件）。我们使用 Cox 回归研究了 ALA 与 CHF 事件的关系。
在校正年龄、性别、种族、教育程度、吸烟状况、BMI、腰围和饮酒量后，血浆磷脂酰胆碱 ALA 与 CHF 事件无关（最高与最低四分位间距的 HR：0.97；95%CI：0.79，1.21；P 趋势=0.85）。同样，饮食 ALA 与 CHF 事件无关（最高与最低四分位间距的调整 HR：0.96；95%CI：0.82，1.20；P 趋势=0.97）。我们没有观察到生物标志物或饮食 ALA 与非瓣膜性 CHF 亚型之间的关联。我们还发现，在基于年龄、性别、糖尿病、鱼类摄入量、BMI 或 FADS2 基因型（rs1535）的亚组中，ALA 与 CHF 之间的关联证据很少。
在老年人中，ALA 摄入量与 CHF 事件无关。这项试验在 clinicaltrials.gov 注册，编号为 NCT00005133。
