接受环孢素A治疗的心脏移植患者中转化生长因子β1（TGF-β1）与牙龈增生的关联。

Association of transforming growth factor β1 (TGF- β1) with gingival hyperplasia in heart transplant patients undergoing cyclosporine-A treatment.

作者信息

Pakosz Katarzyna, Zakliczyński Michał, Król Wojciech, Pyka Lukasz, Zakliczyńska Helena, Trybunia Dominika, Wiench Rafał, Ilewicz Leszek, Skrzep-Poloczek Bronisława, Przybylski Roman, Zembala Marian

机构信息

Department of Conservative Dentistry and Periodontology, Medical University of Silesia, Bytom, Poland.

出版信息

Ann Transplant. 2012 Apr-Jun;17(2):45-52. doi: 10.12659/aot.883222.

DOI:10.12659/aot.883222

PMID:22743722

Abstract

BACKGROUND

Gingival hyperplasia is a common complication of immunosuppressive therapy with cyclosporine A (CyA). However, the association of CyA with increased tissue concentrations of TGF- β(1), a potential causative factor of hyperplasia, remains unknown. The aim of the study was to assess the impact of TGF- β(1) and IL-2 on the development and maintenance of gingival hyperplasia in patients treated with CyA after orthotopic heart transplantation (OHT).

MATERIAL/METHODS: Gingival hyperplasia was indexed in 60 patients, in accordance with McGraw and Potter scale. Patients were divided and comparisons were made among 3 groups: Group A (18 patients; 49.0 ± 12.1 y/o) after OHT with gingival hyperplasia (score 1, 2, 3), Group B (12 patients; 40.0 ± 15.1 y/o) after OHT without gingival hyperplasia (score 0), and Group C - the control group - (30 patients; 42.0 ± 10.8 y/o) with clinically healthy paradentium. Cytokines (TGF- β(1) and IL-2) were marked in gingival tissue homogenate. The concentration of CyA was marked in the patients' blood (Groups A and B).

RESULTS

The highest mean concentration of TGF- β(1) was obtained in Group A and the lowest concentration was in the control group. A positive correlation was found between TGF- β(1) in gingival tissue and CyA blood concentration in Groups A and B.

CONCLUSIONS

TGF- β(1) is associated with gingival hyperplasia in patients treated with CyA after OHT procedure.

摘要

背景

牙龈增生是环孢素A（CyA）免疫抑制治疗的常见并发症。然而，CyA与增生潜在致病因素转化生长因子β1（TGF-β1）组织浓度升高之间的关联尚不清楚。本研究的目的是评估TGF-β1和白细胞介素-2（IL-2）对原位心脏移植（OHT）后接受CyA治疗患者牙龈增生的发生和维持的影响。

材料/方法：根据麦格劳和波特量表对60例患者的牙龈增生进行分度。将患者分为3组并进行比较：A组（18例患者；49.0±12.1岁）为OHT后出现牙龈增生（评分1、2、3）的患者，B组（12例患者；40.0±15.1岁）为OHT后未出现牙龈增生（评分0）的患者，C组为对照组（30例患者；42.0±10.8岁），其牙周组织临床健康。在牙龈组织匀浆中标记细胞因子（TGF-β1和IL-2）。在患者血液中标记CyA的浓度（A组和B组）。