Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Br J Radiol. 2012 Nov;85(1019):e1004-8. doi: 10.1259/bjr/67294268. Epub 2012 Jun 27.
High-resolution CT angiography (CTA) is currently available using multidetector row CT (MDCT); however, its use for small artery visualisation has been limited. To evaluate its capability, we investigated CTA visualisation for difference in number of the lenticulostriate artery (LSA) branches between normotensive and hypertensive patients, because hypertension is a major cause of LSA damage.
This was a retrospective study evaluating cerebrovascular CTA at our hospital conducted from February 2008 to June 2009 under approval of the institutional review board. 117 patients (39 males and 78 females, 19-88 years old) were included. CTA was conducted using a 64 channel MDCT. Total numbers of LSA branches were examined for differences by age with regression analysis and the presence or absence of hypertension and/or aneurysm using two-sample t-tests. A p-value <0.016 was considered statistically significant after correction for multiple comparisons. A multiple variable analysis of three factors was also conducted.
The average number of LSA branches was 3.6 [95% confidence interval (CI) 3.0-4.1] and 4.4 (95% CI 4.1-4.7), respectively, for a patient with and without history of hypertension, and the difference was statistically significant (p=0.013). The difference was approximately one branch in the multiple variable analysis. No significant correlation was observed for age and no significant difference was observed for the presence or absence of aneurysms.
Contrast-enhanced CTA can visualise significant differences in the number of LSA branches among patients with and without hypertension. Advances in knowledge Current high-resolution CTA can visualise LSA well, which enables finding a difference in the LSA between normotensive subjects and hypertensive patients.
高分辨率 CT 血管造影（CTA）目前可使用多排 CT（MDCT）进行；然而，其在小动脉可视化方面的应用受到限制。为了评估其能力，我们研究了 CTA 在正常血压和高血压患者之间观察到的纹状动脉（LSA）分支数量差异，因为高血压是 LSA 损伤的主要原因。
这是一项回顾性研究，评估了我们医院在 2008 年 2 月至 2009 年 6 月期间进行的脑血管 CTA，该研究得到了机构审查委员会的批准。共纳入 117 例患者（39 名男性和 78 名女性，年龄 19-88 岁）。使用 64 排 MDCT 进行 CTA。使用回归分析检查 LSA 分支总数的年龄差异，并使用两样本 t 检验检查高血压和/或动脉瘤的存在或不存在。校正多重比较后，p 值<0.016 被认为具有统计学意义。还进行了三个因素的多变量分析。
有高血压病史和无高血压病史的患者的平均 LSA 分支数分别为 3.6（95%置信区间[CI]3.0-4.1）和 4.4（95%CI 4.1-4.7），差异具有统计学意义（p=0.013）。多变量分析中差异约为一个分支。年龄无显著相关性，动脉瘤的存在与否无显著差异。
增强对比 CTA 可观察到高血压患者和无高血压患者之间 LSA 分支数量的显著差异。知识进展 目前的高分辨率 CTA 可以很好地观察 LSA，这使得我们能够发现正常血压受试者和高血压患者之间的 LSA 差异。
