Rusin Błażej, Kotwicki Tomasz, Głodek Aleksandra, Andrusiewicz Miroslaw, Urbaniak Paulina, Kotwicka Małgorzata
Department of Pediatric Orthopedics and Traumatology, University of Medical Sciences Poznan, Poland.
Stud Health Technol Inform. 2012;176:59-62.
Deep paravertebral muscles and female sex hormones are potential elements participating in idiopathic scoliosis development. Estrogen acts through estrogen receptors: ESR1 and ESR2. There are no studies describing ESR2 expression in back muscles in girls with idiopathic scoliosis. The aim of this study was to evaluate ESR2 expression levels in back muscles on both sides of the spinal curve and correlation between the expression level and scoliosis parameters. Asymmetrical ESR2 expression in deep paravertebral muscles was found: 11 girls had higher expression level on the convex side and 5 girls had higher expression level on the concave side of the curvature. Patients with ESR2 (convex/concave) ratio ≥ 1 presented positive correlation between ESR2 ratio and Cobb angle.
深部椎旁肌和女性性激素是参与特发性脊柱侧凸发展的潜在因素。雌激素通过雌激素受体ESR1和ESR2发挥作用。尚无研究描述特发性脊柱侧凸女孩背部肌肉中ESR2的表达情况。本研究的目的是评估脊柱侧凸曲线两侧背部肌肉中ESR2的表达水平，以及该表达水平与脊柱侧凸参数之间的相关性。研究发现深部椎旁肌中ESR2表达不对称：11名女孩在脊柱侧凸凸侧的表达水平较高，5名女孩在凹侧的表达水平较高。ESR2（凸侧/凹侧）比值≥1的患者，ESR2比值与Cobb角呈正相关。
