Department of Life Science, National Taiwan Normal University, Taipei, Taiwan.
Am J Chin Med. 2012;40(3):643-56. doi: 10.1142/S0192415X12500486.
The mechanism of action of Prunella vulgaris L. (PV) affecting cell migration and invasion of human liver cancer cells remains unknown. In this work we showed that the aqueous extract of PV affected migration and invasion of human liver carcinoma cells by inhibiting activities of metalloproteases, MMP-2 and MMP-9, without affecting cell viabilities. We further showed that PV suppressed migration through attenuation of enzymatic activities of MMP-9 and MMP-2 at transcriptional levels and the effects can be correlated with the status of p53 in hepatocarcinoma cells. This work provides a new dimension of understanding on Prunella vulgaris in restraining migration and invasion in human liver cancer cells.
夏枯草（Prunella vulgaris L.）影响人肝癌细胞迁移和侵袭的作用机制尚不清楚。在这项工作中，我们表明，夏枯草的水提取物通过抑制金属蛋白酶 MMP-2 和 MMP-9 的活性而不影响细胞活力来影响人肝癌细胞的迁移和侵袭。我们进一步表明，夏枯草通过抑制 MMP-9 和 MMP-2 的酶活性在转录水平上抑制迁移，并且这些作用与肝癌细胞中 p53 的状态相关。这项工作为理解夏枯草抑制人肝癌细胞迁移和侵袭提供了一个新的维度。
