心力衰竭中的睡眠呼吸暂停与认知功能
Sleep apnea and cognitive function in heart failure.
作者信息
Knecht Krysten M, Alosco Michael L, Spitznagel Mary Beth, Cohen Ronald, Raz Naftali, Sweet Lawrence, Colbert Lisa H, Josephson Richard, Hughes Joel, Rosneck Jim, Gunstad John
机构信息
Department of Psychology, Kent State University, Kent, OH 44242, USA.
出版信息
Cardiovasc Psychiatry Neurol. 2012;2012:402079. doi: 10.1155/2012/402079. Epub 2012 Jun 14.
Background. Prior research indicates that heart failure (HF) patients exhibit significant cognitive deficits on neuropsychological testing. Sleep apnea is associated with both HF and reduced cognitive function, but the combined impact of these conditions on cognitive function is unknown. Methods. In the current study, 172 older adults with a dual diagnosis of HF and sleep apnea or HF alone completed a battery of cognitive tests measuring attention, executive functioning, and memory. Results. Relative to patients with HF alone, persons with both HF and sleep apnea performed worse on measures of attention after adjusting for demographic and medical variables. Conclusions. The current findings suggest that HF patients with comorbid sleep apnea may be at greater risk for cognitive impairment relative to HF patient without such history. Further work is needed to clarify mechanisms for these findings and to determine whether the interactive effects on cognitive function lead to poorer patient outcomes.
背景。先前的研究表明，心力衰竭（HF）患者在神经心理学测试中表现出显著的认知缺陷。睡眠呼吸暂停与HF和认知功能下降均相关，但这些情况对认知功能的综合影响尚不清楚。方法。在本研究中，172名同时患有HF和睡眠呼吸暂停或仅患有HF的老年人完成了一系列认知测试，以测量注意力、执行功能和记忆力。结果。在调整人口统计学和医学变量后，相对于仅患有HF的患者，同时患有HF和睡眠呼吸暂停的患者在注意力测试中的表现更差。结论。目前的研究结果表明，与没有此类病史的HF患者相比，合并睡眠呼吸暂停的HF患者可能有更高的认知障碍风险。需要进一步的研究来阐明这些发现的机制，并确定对认知功能的交互作用是否会导致患者预后更差。
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