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本文引用的文献

1
Complete genome sequence of Pseudomonas aeruginosa lytic bacteriophage PA1O which resembles temperate bacteriophage D3112.铜绿假单胞菌裂解噬菌体 PA1O 的全基因组序列类似于温和噬菌体 D3112。
J Virol. 2012 Mar;86(6):3400-1. doi: 10.1128/JVI.07191-11.
2
Antibacterial activity of Acinetobacter baumannii phage ϕAB2 endolysin (LysAB2) against both gram-positive and gram-negative bacteria.鲍曼不动杆菌噬菌体 ϕAB2 溶菌酶 (LysAB2) 对革兰氏阳性菌和革兰氏阴性菌的抗菌活性。
Appl Microbiol Biotechnol. 2011 Apr;90(2):529-39. doi: 10.1007/s00253-011-3104-y. Epub 2011 Jan 25.
3
Efficacy of a broad host range lytic bacteriophage against E. coli adhered to urothelium.广谱裂解噬菌体对黏附于尿路上皮的大肠杆菌的疗效。
Curr Microbiol. 2011 Apr;62(4):1128-32. doi: 10.1007/s00284-010-9834-8. Epub 2010 Dec 8.
4
A simple colorimetric method for testing antimicrobial susceptibility of biofilmed bacteria.一种用于测试生物膜细菌抗菌敏感性的简单比色法。
J Microbiol. 2010 Oct;48(5):709-11. doi: 10.1007/s12275-010-0299-z. Epub 2010 Nov 3.
5
Quality-controlled small-scale production of a well-defined bacteriophage cocktail for use in human clinical trials.用于人体临床试验的经过质量控制的特定噬菌体混合物的小规模生产。
PLoS One. 2009;4(3):e4944. doi: 10.1371/journal.pone.0004944. Epub 2009 Mar 20.
6
Production and application of bacteriophage and bacteriophage-encoded lysins.噬菌体及噬菌体编码溶菌酶的生产与应用。
Recent Pat Biotechnol. 2009;3(1):37-45. doi: 10.2174/187220809787172678.
7
Phage classification and characterization.噬菌体分类与鉴定。
Methods Mol Biol. 2009;501:127-40. doi: 10.1007/978-1-60327-164-6_13.
8
Ecology and evolution in microbial systems: the generation and maintenance of diversity in phage-host interactions.微生物系统中的生态学与进化:噬菌体-宿主相互作用中多样性的产生与维持
Res Microbiol. 2008 Jun;159(5):382-9. doi: 10.1016/j.resmic.2008.05.006. Epub 2008 Jun 6.
9
A colorimetric microtiter plate method for assessment of phage effect on Pseudomonas aeruginosa biofilm.一种用于评估噬菌体对铜绿假单胞菌生物膜影响的比色微量滴定板法。
J Microbiol Methods. 2008 Aug;74(2-3):114-8. doi: 10.1016/j.mimet.2008.03.005. Epub 2008 Mar 14.
10
European regulatory conundrum of phage therapy.噬菌体疗法的欧洲监管难题
Future Microbiol. 2007 Oct;2(5):485-91. doi: 10.2217/17460913.2.5.485.

铜绿假单胞菌噬菌体 PA1Ø 需要 IV 型菌毛才能感染,并表现出广泛的杀菌和生物膜清除活性。

Pseudomonas aeruginosa bacteriophage PA1Ø requires type IV pili for infection and shows broad bactericidal and biofilm removal activities.

机构信息

Department of Microbiology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

出版信息

Appl Environ Microbiol. 2012 Sep;78(17):6380-5. doi: 10.1128/AEM.00648-12. Epub 2012 Jun 29.

DOI:10.1128/AEM.00648-12
PMID:22752161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3416619/
Abstract

We isolated a new lytic Pseudomonas aeruginosa phage that requires type IV pili for infection. PA1Ø has a broad bactericidal spectrum, covering Gram-positive and Gram-negative bacteria, and can eradicate biofilm cells. PA1Ø may be developed as a therapeutic agent for biofilm-related mixed infections with P. aeruginosa and Staphylococcus aureus.

摘要

我们分离到一株新的裂解性铜绿假单胞菌噬菌体,该噬菌体感染需要 IV 型菌毛。PA1Ø 具有广谱杀菌活性,覆盖革兰氏阳性和革兰氏阴性细菌,并且可以清除生物膜细胞。PA1Ø 可能被开发为治疗铜绿假单胞菌和金黄色葡萄球菌混合生物膜相关感染的药物。