Johnson R P, Mellors J W
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
J Emerg Med. 1988 Sep-Oct;6(5):401-4. doi: 10.1016/0736-4679(88)90014-5.
Prompt diagnosis and treatment of cyanide poisoning is essential for a successful therapeutic outcome. We present a patient with acute cyanide poisoning in whom venous blood gases disclosed an abnormally high pO2. Prompt treatment of the patient with the cyanide antidote, sodium nitrite plus sodium thiosulfate, rapidly reversed the cardiovascular and central nervous system manifestations of cyanide toxicity. The pathogenesis of cyanide-induced blood gas abnormalities and their potential value in the recognition of cyanide intoxication are discussed. Current treatment recommendations for cyanide poisoning are also reviewed.
氰化物中毒的及时诊断和治疗对于取得成功的治疗效果至关重要。我们报告了一名急性氰化物中毒患者，其静脉血气显示pO2异常升高。用氰化物解毒剂亚硝酸钠加硫代硫酸钠对该患者进行及时治疗，迅速逆转了氰化物中毒的心血管和中枢神经系统表现。本文讨论了氰化物引起的血气异常的发病机制及其在识别氰化物中毒中的潜在价值。还综述了目前关于氰化物中毒的治疗建议。
