De Martino Laura, Mencherini Teresa, Mancini Emilia, Aquino Rita Patrizia, De Almeida Luiz Fernando Rolim, De Feo Vincenzo
Dipartimento di Scienze Farmaceutiche e Biomediche, Università degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano, Salerno, Italy.
Departamento de Botânica, Instituto de Biociências de Botucatu, UNESP-Campu de Botucatu Distrito de Rubião Júnior, S/N, 18.618-000, Botucatu-SP, Brazil.
Int J Mol Sci. 2012;13(5):5406-5419. doi: 10.3390/ijms13055406. Epub 2012 May 4.
The knowledge of flavonoids involved in plant-plant interactions and their mechanisms of action are poor and, moreover, the structural characteristics required for these biological activities are scarcely known. The objective of this work was to study the possible in vitro phytotoxic effects of 27 flavonoids on the germination and early radical growth of Raphanus sativus L. and Lepidium sativum L., with the aim to evaluate the possible structure/activity relationship. Moreover, the antioxidant activity of the same compounds was also evaluated. Generally, in response to various tested flavonoids, germination was only slightly affected, whereas significant differences were observed in the activity of the various tested flavonoids against radical elongation. DPPH test confirms the antioxidant activity of luteolin, quercetin, catechol, morin, and catechin. The biological activity recorded is discussed in relation to the structure of compounds and their capability to interact with cell structures and physiology. No correlation was found between phytotoxic and antioxidant activities.
关于黄酮类化合物在植物与植物相互作用中的作用及其作用机制的了解很少，此外，这些生物活性所需的结构特征也鲜为人知。这项工作的目的是研究27种黄酮类化合物对萝卜和独行菜种子萌发和早期胚根生长可能的体外植物毒性作用，以评估可能的结构/活性关系。此外，还评估了相同化合物的抗氧化活性。一般来说，针对各种测试的黄酮类化合物，萌发仅受到轻微影响，而在各种测试的黄酮类化合物对胚根伸长的活性方面观察到显著差异。DPPH测试证实了木犀草素、槲皮素、儿茶酚、桑色素和儿茶素的抗氧化活性。记录的生物活性与化合物的结构及其与细胞结构和生理相互作用的能力有关进行了讨论。未发现植物毒性和抗氧化活性之间的相关性。
