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静止细胞状态依赖于Arf/p53，并与H2AX下调和基因组稳定性相关。

The quiescent cellular state is Arf/p53-dependent and associated with H2AX downregulation and genome stability.

作者信息

Yoshioka Ken-Ichi, Atsumi Yuko, Fukuda Hirokazu, Masutani Mitsuko, Teraoka Hirobumi

机构信息

Division of Genome Stability Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

Department of Biosciences, School of Science, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara 228-8555, Japan.

出版信息

Int J Mol Sci. 2012;13(5):6492-6506. doi: 10.3390/ijms13056492. Epub 2012 May 24.

DOI:10.3390/ijms13056492
PMID:22754379
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3382772/
Abstract

Cancer is a disease associated with genomic instability and mutations. Excluding some tumors with specific chromosomal translocations, most cancers that develop at an advanced age are characterized by either chromosomal or microsatellite instability. However, it is still unclear how genomic instability and mutations are generated during the process of cellular transformation and how the development of genomic instability contributes to cellular transformation. Recent studies of cellular regulation and tetraploidy development have provided insights into the factors triggering cellular transformation and the regulatory mechanisms that protect chromosomes from genomic instability.

摘要

癌症是一种与基因组不稳定和突变相关的疾病。除了一些具有特定染色体易位的肿瘤外，大多数老年期发生的癌症的特征是染色体不稳定或微卫星不稳定。然而，目前仍不清楚在细胞转化过程中基因组不稳定和突变是如何产生的，以及基因组不稳定的发展如何促进细胞转化。最近关于细胞调控和四倍体发育的研究为触发细胞转化的因素以及保护染色体免受基因组不稳定影响的调控机制提供了见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5169/3382772/6174803b19bf/ijms-13-06492f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5169/3382772/40dc3f3a5e1d/ijms-13-06492f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5169/3382772/bfd9987cf990/ijms-13-06492f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5169/3382772/7ff93785964b/ijms-13-06492f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5169/3382772/44f8ffcb6cd0/ijms-13-06492f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5169/3382772/6174803b19bf/ijms-13-06492f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5169/3382772/40dc3f3a5e1d/ijms-13-06492f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5169/3382772/bfd9987cf990/ijms-13-06492f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5169/3382772/7ff93785964b/ijms-13-06492f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5169/3382772/44f8ffcb6cd0/ijms-13-06492f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5169/3382772/6174803b19bf/ijms-13-06492f5.jpg

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