Hajia Massoud, Rahbar Mohammad, Fallah Fatemeh, Safadel Nooshafarin
Department of Microbiology Iranian Reference Health Laboratory, Ministry of health and medical Education Tehran, Iran.
Open Respir Med J. 2012;6:34-6. doi: 10.2174/1874306401206010034. Epub 2012 Jun 15.
Even with high coverage of vaccination programs, Bordetella pertussis is still reported in various countries. It causes a high rate of mortality and morbidity in infants while it could be asymptomatic in adults. At the present study, we are going to evaluate the frequency of B. pertussis among received specimens.
This cross-sectional study was performed on 138 children under one year who were suspected to have whooping cough from October 2008 to March in 2011. Nasopharyngeal dacron and rayon swabs and sera were used for PCR and serology respectively.
The mean age of the subjects was 1.9± 0.9 months. PCR was positive in 12 cases; ELISA was in agreement with PCR results except in one case that showed the specific antibody at borderline limit.
The rate of reported positive results showed that pertussis not only is still present in the community, but the number of the asymptomatic cases who are able to transmit the disease may be considerable.
即使疫苗接种计划覆盖率很高，各国仍有百日咳博德特氏菌的报告。它在婴儿中导致高死亡率和发病率，而在成人中可能无症状。在本研究中，我们将评估所接收标本中百日咳博德特氏菌的频率。
这项横断面研究对2008年10月至2011年3月期间138名疑似患有百日咳的一岁以下儿童进行。分别使用鼻咽部涤纶和人造纤维拭子以及血清进行PCR和血清学检测。
研究对象的平均年龄为1.9±0.9个月。12例PCR检测呈阳性；ELISA结果与PCR结果一致，只有1例特异性抗体处于临界值。
报告的阳性结果率表明，百日咳不仅在社区中仍然存在，而且能够传播疾病的无症状病例数量可能相当可观。
