低出生体重新生儿与母体血清锌浓度之间的关系。
Relationship between Low Birth Weight Neonate and Maternal Serum Zinc Concentration.
作者信息
Khadem N, Mohammadzadeh A, Farhat A S, Valaee L, Khajedaluee M, Parizadeh S M R
机构信息
Department of Obstetrics and Gynecology, Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Iran Red Crescent Med J. 2012 Apr;14(4):240-4. Epub 2012 Apr 1.
BACKGROUND
Zinc deficiency can lead to clinically relevant disturbances in tissue functions and particularly important for birth weight of neonates. The aim of this study was to determine the relationship between serum zinc in pregnant women and the incidence of low birth weight (<2500 g) in their newborns.
METHODS
This case-control study was done on women who delivered low birth weight infants (Cases), and normal birth weight infants (Controls). Blood samples got in all women within 5 minutes of delivery, and assessed the concentration of zinc using electrothermal atomic absorption spectrometry. Serum concentration of zinc was compared.
RESULTS
One hundred and seventeen mothers were enrolled, of them, 65 cases were low birth weight infants (1845±472 g) and 52 were controls (3166± 435 g). Mothers in the case and control groups did not differ in age, body mass index, and socioeconomic or demographic factors. Maternal zinc concentration differed between cases and controls; 753.34±15 µg/l vs. 654.76±12 µg/l respectively. Maternal zinc differed between premature and full term deliveries.
CONCLUSION
Maternal zinc concentration was shown to affect birth weight and prematurity.
背景
锌缺乏可导致临床上与组织功能相关的紊乱，对新生儿出生体重尤为重要。本研究的目的是确定孕妇血清锌与新生儿低出生体重（<2500克）发生率之间的关系。
方法
本病例对照研究针对分娩低出生体重婴儿的妇女（病例组）和正常出生体重婴儿的妇女（对照组）进行。在所有妇女分娩后5分钟内采集血样，使用电热原子吸收光谱法评估锌浓度。比较血清锌浓度。
结果
共纳入117名母亲，其中65例为低出生体重婴儿（1845±472克），52例为对照组（3166±435克）。病例组和对照组母亲在年龄、体重指数以及社会经济或人口统计学因素方面无差异。病例组和对照组母亲的锌浓度不同；分别为753.34±15微克/升和654.76±12微克/升。早产和足月分娩的母亲锌含量不同。
结论
孕妇锌浓度被证明会影响出生体重和早产情况。
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