Department of Pediatrics, National Center for Global Health and Medicine, Tokyo, Japan.
PLoS One. 2013 Sep 27;8(9):e75627. doi: 10.1371/journal.pone.0075627. eCollection 2013.
Trace elements play important nutritional roles in neonates. Our objective was to examine whether there are differences in maternal/neonatal serum trace element concentrations between mature infants and premature infants.
During 2012, 44 infants born at National Center for Global Health and Medicine, Tokyo, Japan, were enrolled. Serum samples were collected to measure serum iron, zinc, copper, and selenium concentrations 5 days after birth. Maternal serum samples were obtained before delivery and cord blood was taken at delivery to measure the same trace elements. We compared the results between term group whose birth weight were ≥2500 g and gestational age were ≥37 weeks and premature group whose birth weight were <2500 g or gestational age were <37 weeks. Variables significantly different between two groups were included in linear regression models to identify significant predictors of birth weight. Values of P<0.05 were considered statistically significant.
Serum selenium concentrations were lower in premature group than in term group (43.3±7.0 µg/L vs. 52.0±8.9 µg/L, P = 0.001). Maternal serum selenium concentrations were also significantly lower in the mothers of premature group than in the mothers of term group (79.3±19.3 µg/L vs. 94.1±18.1 µg/L, P = 0.032). There were no significant differences in neonatal or maternal iron, zinc, or copper concentrations between two groups. Multivariate linear regression analysis showed that, except for gestational age, only maternal serum selenium was significantly associated with birth weight (P = 0.015).
Serum selenium concentrations were lower in premature group and their mothers compared with the term group. The maternal serum selenium concentration was positively correlated with birth weight. These results suggest that maternal serum selenium concentration may influence neonatal birth weight.
微量元素在新生儿中起着重要的营养作用。我们的目的是研究成熟儿和早产儿的母儿血清微量元素浓度是否存在差异。
2012 年，我们在日本东京国立全球健康与医学中心招募了 44 名婴儿。在出生后 5 天采集血清样本，以测量血清铁、锌、铜和硒的浓度。在分娩前采集产妇血清样本，并在分娩时采集脐血以测量相同的微量元素。我们比较了出生体重≥2500g、胎龄≥37 周的足月组和出生体重<2500g 或胎龄<37 周的早产组之间的结果。将两组间差异有统计学意义的变量纳入线性回归模型，以确定出生体重的显著预测因素。P 值<0.05 被认为具有统计学意义。
与足月组相比，早产组血清硒浓度较低（43.3±7.0μg/L 比 52.0±8.9μg/L，P=0.001）。早产组产妇血清硒浓度也明显低于足月组产妇（79.3±19.3μg/L 比 94.1±18.1μg/L，P=0.032）。两组新生儿或产妇铁、锌、铜浓度无显著差异。多变量线性回归分析显示，除胎龄外，只有产妇血清硒与出生体重显著相关（P=0.015）。
与足月组相比，早产组及其母亲的血清硒浓度较低。产妇血清硒浓度与出生体重呈正相关。这些结果表明，产妇血清硒浓度可能影响新生儿的出生体重。
