Dept of Food and Nutrition, SoongEui Women's College, Seoul 100-751, South Korea.
J Food Sci. 2012 Jul;77(7):H147-52. doi: 10.1111/j.1750-3841.2012.02748.x.
American ginseng (Panax quinquefolius L.) root health benefits include treatment of type 2 diabetes and this study evaluated the hypoglycemic effects of American red ginseng (ARG). ARG roots have increased bioactive phenolic contents, such as cinnamic acid and ferulic acid during the steaming process. The antihyperglycemic effects of methanol fraction extract of ARG, ferulic acid, and cinnamic acid were examined using a type 2 diabetic mouse model. The ARG treated group presented relatively lower blood glucose levels than the control group (P < 0.05). In addition, the glycogen and high density lipoprotein (HDL) contents were significantly increased while levels of plasma cholesterol and low density lipoprotein (LDL) concentration were significantly decreased in the ARG treated group. The groups treated with ferulic and cinnamic acids showed similar effects as those found in the ARG treated group. Thus, it is suggested that ARG roots, ferulic acid, and cinnamic acid have hypoglycemic effects in an animal model.
This study was conducted to elucidate the hypoglycemic effects of American red ginseng (ARG) using a type 2 diabetic mouse model. ARG showed an enhanced antioxidant capacity and higher antihyperglycemia effect. The glycogen and high density lipoprotein (HDL) contents were significantly increased while levels of plasma cholesterol and low density lipoprotein (LDL) concentration were significantly decreased in the ARG treated group. It is suggested that ARG has a potential to be used for human diabetic treatment.
西洋参（Panax quinquefolius L.）根具有治疗 2 型糖尿病的功效，本研究评估了红参（ARG）的降血糖作用。ARG 根在蒸制过程中增加了生物活性酚类物质，如肉桂酸和阿魏酸。使用 2 型糖尿病小鼠模型，研究了 ARG 的甲醇提取物、阿魏酸和肉桂酸的降血糖作用。与对照组相比，ARG 处理组的血糖水平相对较低（P<0.05）。此外，ARG 处理组的肝糖原和高密度脂蛋白（HDL）含量显著增加，而血浆胆固醇和低密度脂蛋白（LDL）浓度显著降低。阿魏酸和肉桂酸处理组表现出与 ARG 处理组相似的效果。因此，ARG 根、阿魏酸和肉桂酸在动物模型中具有降血糖作用。
本研究旨在使用 2 型糖尿病小鼠模型阐明红参（ARG）的降血糖作用。ARG 显示出增强的抗氧化能力和更高的抗高血糖作用。ARG 处理组的肝糖原和高密度脂蛋白（HDL）含量显著增加，而血浆胆固醇和低密度脂蛋白（LDL）浓度显著降低。因此，ARG 有可能用于人类糖尿病的治疗。
