Sommer C, Häuser W, Burgmer M, Engelhardt R, Gerhold K, Petzke F, Schmidt-Wilcke T, Späth M, Tölle T, Uçeyler N, Wang H, Winkelmann A, Thieme K
Neurologische Klinik, Universitätsklinikum Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Deutschland.
Schmerz. 2012 Jun;26(3):259-67. doi: 10.1007/s00482-012-1174-0.
The scheduled update to the German S3 guidelines on fibromyalgia syndrome (FMS) by the Association of the Scientific Medical Societies ("Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften", AWMF; registration number 041/004) was planned starting in March 2011.
The development of the guidelines was coordinated by the German Interdisciplinary Association for Pain Therapy ("Deutsche Interdisziplinären Vereinigung für Schmerztherapie", DIVS), 9 scientific medical societies and 2 patient self-help organizations. Eight working groups with a total of 50 members were evenly balanced in terms of gender, medical field, potential conflicts of interest and hierarchical position in the medical and scientific fields. Literature searches were performed using the Medline, PsycInfo, Scopus and Cochrane Library databases (until December 2010). The grading of the strength of the evidence followed the scheme of the Oxford Centre for Evidence-Based Medicine.
Current data do not identify distinct etiologic or pathophysiological factors mediating development of FMS. The development of FMS is associated with inflammatory rheumatic diseases (EL2b), with gene polymorphisms of the 5-hydroxytryptamine (HT)(2) receptor (EL3a), lifestyle factors (smoking, obesity, lack of physical activity; EL2b), physical and sexual abuse in childhood and adulthood (EL3a).
FMS is most likely the result of various pathogenetic factors and pathophysiological mechanisms. The English full-text version of this article is available at SpringerLink (under "Supplemental").
德国科学医学协会联合会（“Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften”，AWMF；注册号041/004）计划于2011年3月开始对德国纤维肌痛综合征（FMS）的S3指南进行定期更新。
该指南的制定由德国疼痛治疗跨学科协会（“Deutsche Interdisziplinären Vereinigung für Schmerztherapie”，DIVS）、9个科学医学协会和2个患者自助组织协调。8个工作组共有50名成员，在性别、医学领域、潜在利益冲突以及医学和科学领域的层级地位方面实现了均衡。使用Medline、PsycInfo、Scopus和Cochrane图书馆数据库（截至2010年12月）进行文献检索。证据强度分级遵循牛津循证医学中心的方案。
目前的数据尚未确定介导FMS发生发展的独特病因或病理生理因素。FMS的发生与炎性风湿性疾病（EL2b）、5-羟色胺（HT）（2）受体的基因多态性（EL3a）、生活方式因素（吸烟、肥胖缺乏体育活动；EL2b）、儿童期和成年期的身体和性虐待（EL3a）有关。
FMS很可能是多种致病因素和病理生理机制共同作用的结果。本文的英文全文版本可在SpringerLink（“补充材料”下）获取。
