Department of Neurology, University of Würzburg, Josef-Schneider-Str, 11, 97080 Würzburg, Germany.
BMC Musculoskelet Disord. 2011 Oct 28;12:245. doi: 10.1186/1471-2474-12-245.
To perform a systematic review and meta-analysis on cytokine levels in patients with fibromyalgia syndrome (FMS).
Through December 2010 we systematically reviewed the databases PubMed, MEDLINE, and PsycINFO and screened the reference lists of 22 review articles for suitable original articles. Original articles investigating cytokines in patients with FMS were included. Data were extracted by two independent authors. Differences of the cytokine levels of FMS patients and controls were summarized by standardized mean differences (SMD) using a random effects model. Study quality was assessed applying methodological scores: modified Center of Evidence Based Medicine, Newcastle-Ottawa-Scale, and Würzburg Methodological Quality Score.
Twenty-five articles were included investigating 1255 FMS patients and 800 healthy controls. Data of 13/25 studies entered meta-analysis. The overall methodological quality of studies was low. The results of the majority of studies were not comparable because methods, investigated material, and investigated target cytokines differed. Systematic review of the selected 25 articles revealed that FMS patients had higher serum levels of interleukin (IL)-1 receptor antagonist, IL-6, and IL-8, and higher plasma levels of IL-8. Meta-analysis of eligible studies showed that FMS patients had higher plasma IL-6 levels compared to controls (SMD = -0.34 [-0.64, -0.03] 95% CI; p = 0.03). The majority of investigated cytokines were not different between patients and controls.
The pathophysiological role of cytokines in FMS is still unclear. Studies of higher quality and with higher numbers of subjects are needed.
对纤维肌痛综合征（FMS）患者的细胞因子水平进行系统评价和荟萃分析。
截至 2010 年 12 月，我们系统地检索了 PubMed、MEDLINE 和 PsycINFO 数据库，并筛选了 22 篇综述文章的参考文献列表，以寻找合适的原始文章。纳入研究 FMS 患者细胞因子的原始文章。由两位独立作者提取数据。使用随机效应模型，通过标准化均数差（SMD）总结 FMS 患者和对照组细胞因子水平的差异。应用改良循证医学中心、纽卡斯尔-渥太华量表和维尔茨堡方法学质量评分评估研究质量。
纳入了 25 项研究，共调查了 1255 名 FMS 患者和 800 名健康对照者。13/25 项研究的数据纳入荟萃分析。研究的总体方法学质量较低。由于方法、研究材料和研究的目标细胞因子不同，大多数研究的结果无法比较。对 25 篇入选文章进行系统综述显示，FMS 患者血清中白细胞介素（IL）-1 受体拮抗剂、IL-6 和 IL-8 水平较高，血浆中 IL-8 水平较高。合格研究的荟萃分析显示，与对照组相比，FMS 患者的血浆 IL-6 水平更高（SMD = -0.34 [-0.64，-0.03] 95%CI；p = 0.03）。大多数研究的细胞因子在患者和对照组之间无差异。
细胞因子在 FMS 中的病理生理作用仍不清楚。需要进行更高质量和更多样本量的研究。
