Le Han, Tfelt-Hansen Peer, Skytthe Axel, Kyvik Kirsten Ohm, Olesen Jes
The Danish Headache Centre, Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark.
BMJ Open. 2012 Jul 2;2(4). doi: 10.1136/bmjopen-2012-000962. Print 2012.
It is uncertain whether migraine prevalence has increased in modern society. The aim of this study was to assess any change in migraine prevalence over an 8-year period among the adult population in Denmark.
Prospective longitudinal population-based study.
30 000 twin individuals were invited to participate in two cross-sectional questionnaire surveys containing validated questions to diagnose migraine in 1994 and 2002. The twins are representative of the Danish population with regard to migraine and other somatic diseases.
The 1994 cohort comprised 28 571 twin individuals aged 12-41 years and the 2002 cohort 31 865 twin individuals aged 20-71 years.
Sex-, age- and subtype-specific incidence and lifetime prevalence as well as 1-year prevalence of migraine.
1-year prevalence in 2002 was 12.3% for migraine, 4.1% for migraine with aura and 8.2% for migraine without aura. Lifetime prevalence of migraine was 16.1% in 1994 (aged 12-41 years) and 25.2% in 2002 (aged 20-71 years). Lifetime prevalence of migraine for age 20-41 was increased from 1994 to 2002 (18.5% vs 24.5%) by 32.2% (95% CI 27.0% to 37.3%; p<0.001). The difference was primarily seen in the population older than 32 years. The increase was especially evident in migraine with aura (5.6% vs 9.4%, p<0.001) but also a significant increase in migraine without aura was found (13.0% vs 15.1%, p<0.001). Eight-year period incidence rate of migraine was 0.141 corresponding to an average annual incidence rate of 17.6 per 1000 person-years.
Lifetime prevalence of migraine in Denmark increased substantially from 1994 to 2002. Part of the increase may be due to increased medical consultation resulting in increased rate of physician diagnosis or awareness due to previously participation in the 1994 survey. It is pertinent to study the environmental causes of the increase and to implement preventive measures.
现代社会中偏头痛患病率是否上升尚不确定。本研究旨在评估丹麦成年人群在8年期间偏头痛患病率的任何变化。
基于人群的前瞻性纵向研究。
邀请30000对双胞胎个体参与1994年和2002年的两次横断面问卷调查，问卷包含经过验证的用于诊断偏头痛的问题。这些双胞胎在偏头痛和其他躯体疾病方面代表了丹麦人群。
1994年队列包括28571对年龄在12 - 41岁的双胞胎个体，2002年队列包括31865对年龄在20 - 71岁的双胞胎个体。
按性别、年龄和亚型分类的偏头痛发病率、终生患病率以及1年患病率。
2002年偏头痛的1年患病率为12.3%，有先兆偏头痛为4.1%，无先兆偏头痛为8.2%。1994年（年龄12 - 41岁）偏头痛的终生患病率为16.1%，2002年（年龄20 - 71岁）为25.2%。20 - 41岁年龄段偏头痛的终生患病率从1994年到2002年有所增加（18.5%对24.5%），增幅为32.2%（95%可信区间27.0%至37.3%；p<0.001）。这种差异主要见于32岁以上人群。有先兆偏头痛的增加尤为明显（5.6%对9.4%，p<0.001），无先兆偏头痛也有显著增加（13.0%对15.1%，p<0.001）。偏头痛的8年发病率为0.141，相当于每1000人年平均发病率为17.6。
从1994年到2002年，丹麦偏头痛的终生患病率大幅上升。部分增加可能是由于医疗咨询增加导致医生诊断率提高或因先前参与1994年调查而提高了知晓率。研究患病率上升的环境原因并实施预防措施很有必要。
