Lahbabi Mounia, Aqodad Nouredine, Ibrahimi Adil, Lahlou Mryem, Aqodad Hafid
Mounia Lahbabi, Nouredine Aqodad, Adil Ibrahimi, Department of Hepato-Gastroenterology, Hassan II University Hospital, Fes 30000, Morocco.
World J Hepatol. 2012 Jun 27;4(6):196-8. doi: 10.4254/wjh.v4.i6.196.
Amiodarone chlorhydrate is a diiodated benzofuran derivative used to treat cardiac rhythm abnormalities. Hepatotoxicity is a relatively uncommon side effect of amiodarone and symptomatic hepatic dysfunction occurs in less than 1% to 3% of patients taking amiodarone. We report here on an unusual case of amiodarone-induced hepatotoxicity. A 29 year old woman with normal liver function was given amiodarone intravenously to treat her atrial fibrillation. She developed acute toxic hepatitis after 24 h. The intravenous form of amiodarone was immediately avoided and replaced by the oral form, using conventional loading doses as soon as the deranged liver function tests had normalized, without recurrence of the hepatitis. These observations show that the occurrence of acute hepatic impairment with intravenous amiodarone does not necessarily preclude the use of this drug by mouth and the necessity of monitoring the hepatic function of patients treated with amiodarone.
盐酸胺碘酮是一种用于治疗心律失常的二碘苯并呋喃衍生物。肝毒性是胺碘酮相对不常见的副作用，服用胺碘酮的患者中出现症状性肝功能障碍的比例不到1%至3%。我们在此报告一例罕见的胺碘酮所致肝毒性病例。一名肝功能正常的29岁女性因心房颤动接受静脉注射胺碘酮治疗。24小时后她出现了急性中毒性肝炎。立即停用静脉用胺碘酮，改用口服制剂，一旦肝功能检查指标恢复正常，即采用常规负荷剂量给药，肝炎未再复发。这些观察结果表明，静脉注射胺碘酮引起急性肝损伤并不一定排除口服该药物的可能性，同时也表明监测接受胺碘酮治疗患者肝功能的必要性。
