Hjortsø E, Fomsgaard J S, Fogh-Andersen N
Department of Anaesthesiology, Herlev Hospital, University of Copenhagen, Denmark.
Eur J Clin Pharmacol. 1990;39(1):29-31. doi: 10.1007/BF02657052.
N-Acetylcysteine (NAC) is known to decrease the exacerbation rate in patients with chronic bronchitis. It has also been shown that NAC has both an oxygen-radical scavenger and a heavy-metal chelating effect in high intravenous doses. In a study lasting 5 weeks, 10 healthy volunteers were treated with NAC 200 mg t.d.s. for two weeks. The concentrations of trace metals (Ca, Mg, Fe, Zn & Cu) in plasma were measured weekly and daily in a morning spot urine during the investigation. No significant change in plasma concentration or excretion was found during the two weeks of treatment, implying that additional administration of trace metals is unnecessary for patients treated perorally with a therapeutic dose of NAC.
已知N-乙酰半胱氨酸（NAC）可降低慢性支气管炎患者的急性加重率。研究还表明，高静脉剂量的NAC具有氧自由基清除剂和重金属螯合作用。在一项为期5周的研究中，10名健康志愿者接受了为期两周的每日三次、每次200毫克NAC治疗。在研究期间，每周测量血浆中微量元素（钙、镁、铁、锌和铜）的浓度，并在每天晨尿中进行测量。在治疗的两周内，未发现血浆浓度或排泄有显著变化，这意味着对于口服治疗剂量NAC的患者，无需额外补充微量元素。
