Department of Internal Medicine, Saint Joseph Hospital/University of Illinois at Chicago, 2900 North Lake Shore Drive, IL 60657, USA.
Future Oncol. 2012 Jun;8(6):757-60. doi: 10.2217/fon.12.40.
Here, we present an observational case report of choroidal involvement of subcutaneous diffuse large B-cell lymphoma (DLBCL). An 85-year-old female presented with a growing mass on her left abdominal wall that had been gradually growing over 2 months, which was diagnosed as subcutaneous DLBCL. A total of 1.5 months after her initial diagnosis, she presented with decreased peripheral vision of her right eye with intermittent pain for 1 month, and nausea and dizziness for 3 days. A large choroidal mass with vitreous seeding was found and vitreous aspiration with flow cytometry established the diagnosis of intraocular DLBCL. No tumorous lesions were detected anywhere else. Therefore, the patient was diagnosed as stage IV subcutaneous DLBCL with solely intraocular involvement, and was subsequently treated with systemic and intravitreal chemotherapy. A total of 9 months later, she achieved complete remission. It was concluded that subcutaneous extranodal DLBCL is a very rare form of non-Hodgkin lymphoma that can involve only the choroid.
本文报告了一例皮下弥漫性大 B 细胞淋巴瘤（DLBCL）累及脉络膜的观察性病例。一名 85 岁女性因左腹壁逐渐增大的肿块就诊，2 个月来肿块逐渐增大，被诊断为皮下 DLBCL。在最初诊断后的 1.5 个月，她出现右眼周边视力下降，伴有间歇性疼痛 1 个月，恶心和头晕 3 天。发现右眼有一个大脉络膜肿块，伴有玻璃体播散，玻璃体抽吸并进行流式细胞术确立了眼内 DLBCL 的诊断。其他部位未发现肿瘤病变。因此，患者被诊断为仅累及眼内的 IV 期皮下 DLBCL，随后接受全身和玻璃体内化疗。9 个月后，她达到完全缓解。结论认为，皮下结外 DLBCL 是一种非常罕见的非霍奇金淋巴瘤形式，仅可累及脉络膜。
