Fradin M S, Ellis C N, Voorhees J J
Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109-0314.
J Am Acad Dermatol. 1990 Dec;23(6 Pt 2):1265-73; discussion 1273-5. doi: 10.1016/0190-9622(90)70353-j.
Cyclosporine has been used in the experimental treatment of multiple inflammatory diseases of presumed autoimmune origin, including insulin-dependent diabetes mellitus, uveitis, rheumatoid arthritis, inflammatory bowel diseases, Graves' disease, and myasthenia gravis. In dermatology, the drug has been used successfully as primary therapy for psoriasis and psoriatic arthritis, alopecia areata, pyoderma gangrenosum, Behçet's disease, atopic dermatitis, and lichen planus. At a dose of 3 to 5 mg/kg per day, cyclosporine is well tolerated by most patients. However, because of concerns about its potential short- and long-term side effects, patients who use this drug require close monitoring. This review discusses appropriate clinical and laboratory evaluations, common and unusual side effects and their management, drugs that might alter the pharmacokinetics of cyclosporine metabolism, and criteria for dosage adjustments.
环孢素已被用于多种推测为自身免疫性起源的炎症性疾病的实验性治疗，包括胰岛素依赖型糖尿病、葡萄膜炎、类风湿性关节炎、炎症性肠病、格雷夫斯病和重症肌无力。在皮肤科，该药物已成功用作银屑病和银屑病关节炎、斑秃、坏疽性脓皮病、白塞病、特应性皮炎和扁平苔藓的主要治疗方法。大多数患者每天服用3至5毫克/千克的剂量时，对环孢素耐受性良好。然而，由于担心其潜在的短期和长期副作用，使用该药物的患者需要密切监测。本综述讨论了适当的临床和实验室评估、常见和不常见的副作用及其管理、可能改变环孢素代谢药代动力学的药物以及剂量调整标准。
