Gupta A K, Ellis C N, Nickoloff B J, Goldfarb M T, Ho V C, Rocher L L, Griffiths C E, Cooper K D, Voorhees J J
Department of Dermatology, University of Michigan Medical School, Ann Arbor.
Arch Dermatol. 1990 Mar;126(3):339-50.
Cyclosporine is known to be effective in the treatment of psoriasis. In this study, we have used oral cyclosporine (6 mg/kg per day) given for 5 to 30 weeks to 24 patients for the treatment of 12 different dermatoses. Patients with the following diseases demonstrated a marked response or total clearing: 1 patient each with pyoderma gangrenosum, pityriasis lichenoides chronica, and psoriasis of the acrodermatitis continua of Hallopeau type. Moderate to marked response occurred in both patients with epidermolysis bullosa acquisita and the patient with hidradenitis suppurativa. Minimal to moderate responses were obtained in both patients with granuloma annulare, 1 of 2 with acrodermatitis continua of Hallopeau, both patients with Darier's disease, and 1 of 6 patients with vitiligo. Little or no response was noted in both patients with sarcoidosis, all 3 patients with pityriasis rubra pilaris, 5 of 6 patients with vitiligo, 1 patient with pemphigus foliaceous, and 1 with pemphigus vulgaris. Clinical side effects were mild and transient and included dysesthesia, fatigue, hypertrichosis, nausea, and flushing. The most frequent clinically significant abnormalities were hypertension and renal dysfunction, with all factors normalizing within 1 month of discontinuation of cyclosporine therapy.
已知环孢素在银屑病治疗中有效。在本研究中，我们对24例患者使用口服环孢素（每日6mg/kg），给药5至30周，以治疗12种不同的皮肤病。患有以下疾病的患者表现出明显反应或完全清除：各有1例坏疽性脓皮病、慢性苔藓样糠疹以及Hallopeau型连续性肢端皮炎型银屑病患者。获得性大疱性表皮松解症的2例患者以及化脓性汗腺炎患者均出现中度至明显反应。2例环状肉芽肿患者、2例Hallopeau型连续性肢端皮炎患者中的1例、2例 Darier病患者以及6例白癜风患者中的1例获得最小至中度反应。结节病的2例患者、3例毛发红糠疹患者、6例白癜风患者中的5例、1例落叶型天疱疮患者以及1例寻常型天疱疮患者几乎没有或没有反应。临床副作用轻微且短暂，包括感觉异常、疲劳、多毛症、恶心和潮红。最常见的具有临床意义的异常是高血压和肾功能不全，所有这些因素在停用环孢素治疗后1个月内均恢复正常。
