College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China.
Molecules. 2012 Jul 6;17(7):8159-73. doi: 10.3390/molecules17078159.
The objective of this study was to test the hypothesis that p-cymene can attenuate acute lung injury induced by lipopolysaccharide (LPS) in vivo. In the mouse model of LPS-induced acute lung injury, intraperitoneal preconditioning with p-cymene resulted in a significant reduction of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), lung water gain, inflammatory cell infiltration, lung tissue myeloperoxidase activity. In addition, p-cymene blocked the phosphorylation of IκBα protein and mitogen-activated protein kinases (MAPK) signaling pathway activation. Histopathologic examination of lung tissue indicated that p-cymene treatment markedly decreased focal thickening, congestion, pulmonary edema, and inflammatory cells infiltration. The results showed that p-cymene had a protective effect on LPS-induced ALI in mice.
本研究旨在验证对伞花烃（p-cymene）可减轻脂多糖（LPS）诱导的急性肺损伤这一假说。在 LPS 诱导的急性肺损伤小鼠模型中，腹腔预处理对伞花烃可显著降低促炎细胞因子（TNF-α、IL-1β 和 IL-6）、肺水含量、炎症细胞浸润、肺组织髓过氧化物酶活性。此外，对伞花烃可阻断 IκBα 蛋白磷酸化和丝裂原活化蛋白激酶（MAPK）信号通路的激活。肺组织的组织病理学检查表明，对伞花烃治疗可显著减少局灶性增厚、充血、肺水肿和炎症细胞浸润。结果表明，对伞花烃对 LPS 诱导的小鼠 ALI 具有保护作用。
