• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

人参对心脏保护作用的角色与机制。

Roles and mechanisms of ginseng in protecting heart.

机构信息

Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing 100039, China.

出版信息

Chin J Integr Med. 2012 Jul;18(7):548-55. doi: 10.1007/s11655-012-1148-1. Epub 2012 Jul 7.

DOI:10.1007/s11655-012-1148-1
PMID:22772919
Abstract

Ginseng, the root of Panax ginseng C. A. Mayer, has long been used clinically in China to treat various diseases. Multiple effects of ginseng, such as antitumor, antiinflammatory, antiallergic, antioxidative, antidiabetic and antihypertensive have been confirmed by modern medicine. Recently, the clinical utilization of ginseng to treat heart diseases has increased dramatically. The roles of ginseng in protecting heart are foci for research in modern medical science and have been partially demonstrated, and the mechanisms of protection against coronary artery disease, cardiac hypertrophy, heart failure, cardiac energy metabolism, cardiac contractility, and arrhythmia are being uncovered progressively. However, more studies are needed to elucidate the complex mechanisms by which ginseng protects heart. All such studies will provide evidence of ginseng's clinical application, international promotion, and new drug development.

摘要

人参是五加科植物人参 Panax ginseng C. A. Mayer 的根,在中国临床上一直被用于治疗各种疾病。现代医学已经证实了人参的多种作用,如抗肿瘤、抗炎、抗过敏、抗氧化、抗糖尿病和抗高血压。最近,人参在治疗心脏病方面的临床应用急剧增加。人参保护心脏的作用是现代医学研究的焦点,部分作用机制已经得到证实,其对冠状动脉疾病、心肌肥大、心力衰竭、心脏能量代谢、心肌收缩性和心律失常的保护机制也在逐步揭示。然而,还需要更多的研究来阐明人参保护心脏的复杂机制。所有这些研究都将为人参的临床应用、国际推广和新药开发提供证据。

相似文献

1
Roles and mechanisms of ginseng in protecting heart.人参对心脏保护作用的角色与机制。
Chin J Integr Med. 2012 Jul;18(7):548-55. doi: 10.1007/s11655-012-1148-1. Epub 2012 Jul 7.
2
Overview of Panax ginseng and its active ingredients protective mechanism on cardiovascular diseases.人参及其活性成分对心血管疾病保护作用的概述。
J Ethnopharmacol. 2024 Nov 15;334:118506. doi: 10.1016/j.jep.2024.118506. Epub 2024 Jul 2.
3
The saponin of red ginseng protects the cardiac myocytes against ischemic injury in vitro and in vivo.红参的皂甙对心肌细胞具有保护作用,可减轻体内外的缺血性损伤。
Phytomedicine. 2012 Apr 15;19(6):477-83. doi: 10.1016/j.phymed.2012.01.002. Epub 2012 Feb 16.
4
Cardioprotection by ginseng: experimental and clinical evidence and underlying mechanisms.人参的心脏保护作用:实验与临床证据及潜在机制
Can J Physiol Pharmacol. 2018 Sep;96(9):859-868. doi: 10.1139/cjpp-2018-0192. Epub 2018 Jun 25.
5
Ginseng reverses established cardiomyocyte hypertrophy and postmyocardial infarction-induced hypertrophy and heart failure.人参可逆转已建立的心肌细胞肥大以及心肌梗死后引起的心肌肥大和心力衰竭。
Circ Heart Fail. 2012 Jul 1;5(4):504-14. doi: 10.1161/CIRCHEARTFAILURE.112.967489. Epub 2012 May 10.
6
The ginseng's fireness is associated with the lowering activity of liver Na(+)-K(+)-ATPase.人参的温热性与肝脏钠钾ATP酶活性降低有关。
J Ethnopharmacol. 2016 Aug 22;190:241-50. doi: 10.1016/j.jep.2016.06.024. Epub 2016 Jun 8.
7
[Ginseng prescription rules and molecular mechanism in treating coronary heart disease based on data mining and integrative pharmacology].基于数据挖掘和整合药理学的人参治疗冠心病的用药规律及分子机制研究
Zhongguo Zhong Yao Za Zhi. 2018 Apr;43(7):1303-1309. doi: 10.19540/j.cnki.cjcmm.20180115.006.
8
Improved isolated heart contractility and mitochondrial oxidation after chronic treatment with Panax ginseng in rats.大鼠长期服用人参后,离体心脏收缩力和线粒体氧化作用增强。
Am J Chin Med. 1994;22(3-4):275-84. doi: 10.1142/S0192415X94000334.
9
Total ginsenosides of Radix Ginseng modulates tricarboxylic acid cycle protein expression to enhance cardiac energy metabolism in ischemic rat heart tissues.人参总皂苷通过调节三羧酸循环蛋白表达增强缺血性大鼠心脏组织的心脏能量代谢。
Molecules. 2012 Oct 29;17(11):12746-57. doi: 10.3390/molecules171112746.
10
Potential cardioprotective effects of Ginseng preparations.人参制剂的潜在心脏保护作用。
Pak J Pharm Sci. 2015 May;28(3):963-8.

引用本文的文献

1
Ecological shifts in soil microbiota and root rot disease progress during ginseng monoculture.人参连作期间土壤微生物群的生态变化与根腐病病情进展
Front Microbiol. 2024 Oct 18;15:1442208. doi: 10.3389/fmicb.2024.1442208. eCollection 2024.
2
Transcriptome analysis provides insights into the cell wall and aluminum toxicity related to rusty root syndrome of .转录组分析为与[植物名称]锈根综合征相关的细胞壁和铝毒性研究提供了见解。 (原文中“of”后面缺少具体植物名称)
Front Plant Sci. 2023 Jun 13;14:1142211. doi: 10.3389/fpls.2023.1142211. eCollection 2023.
3
Ginsenoside Re inhibits myocardial fibrosis by regulating miR-489/myd88/NF-κB pathway.

本文引用的文献

1
454 EST analysis detects genes putatively involved in ginsenoside biosynthesis in Panax ginseng.454 EST 分析检测到与人参皂苷生物合成相关的假定基因。
Plant Cell Rep. 2011 Sep;30(9):1593-601. doi: 10.1007/s00299-011-1070-6. Epub 2011 Apr 12.
2
Active ingredients in Chinese medicines promoting blood circulation as Na+/K+ -ATPase inhibitors.具有促进血循环作用的中药的有效成分是 Na+/K+-ATP 酶抑制剂。
Acta Pharmacol Sin. 2011 Feb;32(2):141-51. doi: 10.1038/aps.2010.197.
3
Isolation and analysis of ginseng: advances and challenges.
人参皂苷Re通过调节miR-489/myd88/NF-κB通路抑制心肌纤维化。
J Ginseng Res. 2023 Mar;47(2):218-227. doi: 10.1016/j.jgr.2021.11.009. Epub 2021 Dec 2.
4
Transcriptome expression profile of compound-K-enriched red ginseng extract (DDK-401) in Korean volunteers and its apoptotic properties.富含化合物-K的红参提取物(DDK-401)在韩国志愿者中的转录组表达谱及其凋亡特性。
Front Pharmacol. 2022 Dec 1;13:999192. doi: 10.3389/fphar.2022.999192. eCollection 2022.
5
Effects of on hyperglycemia, hypertension, and hyperlipidemia: A systematic review and meta-analysis.[具体物质]对高血糖、高血压和高脂血症的影响:一项系统评价和荟萃分析。 (注:原文中“Effects of on...”部分缺少具体物质,这里保留原文格式并添加了注释说明)
J Ginseng Res. 2022 Mar;46(2):188-205. doi: 10.1016/j.jgr.2021.10.002. Epub 2021 Oct 13.
6
Molecular Cloning and Identification of NADPH Cytochrome P450 Reductase from .从.中克隆和鉴定 NADPH 细胞色素 P450 还原酶。
Molecules. 2021 Nov 3;26(21):6654. doi: 10.3390/molecules26216654.
7
and Extracts Improve Healthspan of Aging Flies and Provide Protection in A Huntington Disease Model.提取物可改善衰老果蝇的健康寿命,并在亨廷顿舞蹈病模型中提供保护。
Aging Dis. 2021 Apr 1;12(2):425-440. doi: 10.14336/AD.2020.0714-1. eCollection 2021 Apr.
8
Treatment of An Acute Severe Cadmium Poisoning Patient Combined with Multiple Organ Dysfunction Syndromes by Integrated Chinese and Western Medicines: A Case Report.中西医结合治疗急性重度镉中毒合并多器官功能障碍综合征 1 例报告
Chin J Integr Med. 2020 Nov;26(11):853-856. doi: 10.1007/s11655-020-3089-4. Epub 2020 Apr 21.
9
Comprehensive comparative analysis of chloroplast genomes from seven species and development of an authentication system based on species-unique single nucleotide polymorphism markers.七种植物叶绿体基因组的综合比较分析及基于物种特异性单核苷酸多态性标记的鉴定系统开发
J Ginseng Res. 2020 Jan;44(1):135-144. doi: 10.1016/j.jgr.2018.06.003. Epub 2018 Jun 22.
10
Microbial Community Changes in the Rhizosphere Soil of Healthy and Rusty and Discovery of Pivotal Fungal Genera Associated with Rusty Roots.健康和锈病根际土壤中微生物群落的变化及与锈病根相关关键真菌属的发现。
Biomed Res Int. 2020 Jan 15;2020:8018525. doi: 10.1155/2020/8018525. eCollection 2020.
人参的分离与分析:进展与挑战。
Nat Prod Rep. 2011 Mar;28(3):467-95. doi: 10.1039/c0np00057d. Epub 2011 Jan 24.
4
Ginseng inhibits cardiomyocyte hypertrophy and heart failure via NHE-1 inhibition and attenuation of calcineurin activation.人参通过抑制 NHE-1 和减弱钙调神经磷酸酶的激活来抑制心肌细胞肥大和心力衰竭。
Circ Heart Fail. 2011 Jan;4(1):79-88. doi: 10.1161/CIRCHEARTFAILURE.110.957969. Epub 2010 Oct 22.
5
Total ginsenosides increase coronary perfusion flow in isolated rat hearts through activation of PI3K/Akt-eNOS signaling.总皂苷通过激活 PI3K/Akt-eNOS 信号通路增加离体大鼠心脏的冠脉灌注流量。
Phytomedicine. 2010 Nov;17(13):1006-15. doi: 10.1016/j.phymed.2010.06.012. Epub 2010 Aug 17.
6
Red ginseng extract improves coronary flow reserve and increases absolute numbers of various circulating angiogenic cells in patients with first ST-segment elevation acute myocardial infarction.红参提取物可改善首次 ST 段抬高型急性心肌梗死患者的冠状动脉血流储备,并增加各种循环血管生成细胞的绝对数量。
Phytother Res. 2011 Feb;25(2):239-49. doi: 10.1002/ptr.3250.
7
Bradyarrhythmia caused by ginseng in a patient with chronic kidney disease.慢性肾病患者因人参导致的缓慢性心律失常。
Am J Emerg Med. 2010 May;28(4):538.e5-6. doi: 10.1016/j.ajem.2009.08.006. Epub 2010 Mar 9.
8
An essential role of Nrf2 in American ginseng-mediated anti-oxidative actions in cardiomyocytes.Nrf2 在西洋参介导的心肌细胞抗氧化作用中的重要作用。
J Ethnopharmacol. 2010 Jul 20;130(2):222-30. doi: 10.1016/j.jep.2010.03.040. Epub 2010 May 4.
9
Role of nitric oxide in ginsenoside Rg(1)-induced protection against left ventricular hypertrophy produced by abdominal aorta coarctation in rats.一氧化氮在人参皂苷 Rg(1)防治腹主动脉缩窄大鼠左心室肥厚中的作用。
Biol Pharm Bull. 2010;33(4):631-5. doi: 10.1248/bpb.33.631.
10
Ginsenoside Rg3 activates human KCNQ1 K+ channel currents through interacting with the K318 and V319 residues: a role of KCNE1 subunit.人参皂苷 Rg3 通过与 K318 和 V319 残基相互作用激活人 KCNQ1 K+ 通道电流:KCNE1 亚基的作用。
Eur J Pharmacol. 2010 Jul 10;637(1-3):138-47. doi: 10.1016/j.ejphar.2010.04.001. Epub 2010 Apr 21.