Toh H T
Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan.
Am J Chin Med. 1994;22(3-4):275-84. doi: 10.1142/S0192415X94000334.
Heart mitochondria freshly isolated from ginseng treated rats respired higher at ADP-induced, state 3 respiratory rates and with greater respiratory indices. These mitochondria were less susceptible to experimentally-induced functional impairment. Control heart mitochondria incubated with ginseng extract also showed that ginseng prevented mitochondria from incubation induced deterioration with NAD-linked substrates. Comparison of force of contraction of isolated, perfused and electrically paced hearts showed that deterioration of the force of heart contraction was consistently smaller throughout the experiment in hearts from ginseng treated rats. These results indicated that Panax ginseng was able to delay experimentally induced heart mitochondrial impairment and muscle contraction deterioration.
从人参处理的大鼠新鲜分离的心脏线粒体在ADP诱导的状态3呼吸速率下呼吸更高，且呼吸指数更大。这些线粒体对实验诱导的功能损伤更不敏感。用人参提取物孵育的对照心脏线粒体也表明，人参可防止线粒体在与NAD相关底物孵育时发生退化。对分离、灌注和电刺激的心脏收缩力的比较表明，在整个实验过程中，人参处理大鼠的心脏收缩力退化始终较小。这些结果表明，人参能够延缓实验诱导的心脏线粒体损伤和肌肉收缩退化。
