Instituto de Ciências Agrárias, Universidade Federal de Minas Gerais, Av Universitária 1000, Bairro Universitário, Montes Claros, MG 39400-006, Brazil.
Parasitol Res. 2012 Dec;111(6):2467-71. doi: 10.1007/s00436-012-3017-4. Epub 2012 Jul 7.
The principal health problem in small ruminants is helminthiasis and the rapid development of nematode resistance to anthelminthics has limited the success of control in several countries, stimulating the search for alternatives. In this study, extracts of immature fruits of the mango Mangifera indica L. var Ubá were evaluated for inhibition of larval development and fecal egg count reduction in sheep naturally infected with gastrointestinal nematodes. In the phytochemical analyses, tannins and flavonoids were the metabolites identified. Aqueous extracts of immature fruits at 100 mg ml(-1) showed 100 % inhibition of larval development. The LC(90) of the extract was 35.9 mg ml(-1) and the in vivo anthelminthic efficacy at 0.740 g kg(-1) (BW, orally) was 53 %. The identification of larvae showed that 99.8 % were Haemonchus spp. In vitro and in vivo results indicate that this fruit could assist ovine nematode control.
小型反刍动物的主要健康问题是寄生虫病，线虫对驱虫药物的快速耐药性限制了一些国家的控制效果，这刺激了人们寻找替代方法。在这项研究中，评估了芒果 Mangifera indica L. var Ubá 的未成熟果实提取物对绵羊胃肠道线虫自然感染的幼虫发育抑制和粪便虫卵计数减少的作用。在植物化学分析中，鉴定出了单宁和类黄酮等代谢物。在 100mg/ml(-1)浓度下，未成熟果实的水提物显示出 100%的幼虫发育抑制率。该提取物的 LC(90)为 35.9mg/ml(-1)，以 0.740g/kg(-1)（BW，口服）的体内驱虫效力为 53%。幼虫的鉴定表明，99.8%为 Haemonchus spp。体外和体内结果表明，这种水果可能有助于绵羊线虫病的控制。
