Instituto de Ciências Agrárias, Universidade Federal de Minas Gerais, Av Universitária 1000, Bairro Universitário, Montes Claros, MG 39400-006, Brazil.
Vet Parasitol. 2010 Aug 4;171(3-4):361-4. doi: 10.1016/j.vetpar.2010.03.043. Epub 2010 Apr 10.
The rapid development of nematode resistance to anthelmintics has limited the success of small ruminant gastrointestinal helminthiasis control in several countries, stimulating the search for alternatives. The aim of this work was to evaluate the in vitro anthelmintic activity of Anacardium humile (Anacardiaceae) on gastrointestinal nematodes of sheep. Aqueous and ethanolic extracts of A. humile leaves were evaluated by the larval development inhibition assay at concentrations of: 187.5, 150, 100, 50, and 30 mg ml(-1); and 100, 80, 60, 40, and 20 mg ml(-1), respectively. Phytochemical analysis demonstrated the presence of tannins, flavenoids, and alkaloids in the leaves. The LD(50) was 10.14 mg ml(-1) for the aqueous extract and 23.24 mg ml(-1) for the ethanolic extract, providing evidence for the potential of this plant in the endoparasite control.
线虫对驱虫药的快速耐药性限制了一些国家中小反刍动物胃肠道蠕虫病控制的成功，这刺激了人们寻找替代品。本研究的目的是评估巴西栗（漆树科）叶的水提物和醇提物对绵羊胃肠道线虫的体外驱虫活性。幼虫发育抑制试验的浓度分别为：187.5、150、100、50 和 30 mg ml(-1)；以及 100、80、60、40 和 20 mg ml(-1)。植物化学分析表明，叶片中存在单宁、类黄酮和生物碱。水提物的 LD(50)为 10.14 mg ml(-1)，醇提物的 LD(50)为 23.24 mg ml(-1)，这为该植物在体内寄生虫控制方面的潜力提供了证据。
