National Institute of Gastroenterology "S. de Bellis", Research Hospital, 70013 Castellana Grotte (Bari), Italy.
Int J Mol Sci. 2020 Feb 15;21(4):1319. doi: 10.3390/ijms21041319.
Dendritic cells (DCs) are antigen-presenting cells with a key role in immune responses. They act as a link between the innate and adaptive systems and they can induce and maintain immunologic tolerance. DCs are subdivided into conventional and plasmacytoid DCs. These cell subsets originate from the same bone marrow precursors and their differentiation process is determined by several extrinsic and intrinsic factors, such as cytokines, transcription factors, and miRNAs. miRNAs are small non-coding RNAs that play a crucial role in modulating physiological and pathological processes mediated by DCs. miRNA deregulation affects many inflammatory conditions and diseases. The aim of this review was to underline the importance of miRNAs in inflammatory processes mediated by DCs in physiological and pathological conditions and to highlight their potential application for future therapies.
树突状细胞（DCs）是具有关键作用的抗原呈递细胞，它们在免疫反应中发挥作用。它们是先天和适应性系统之间的联系，能够诱导和维持免疫耐受。DC 可分为经典型和浆细胞样 DC。这些细胞亚群起源于相同的骨髓前体，其分化过程由多种外在和内在因素决定，如细胞因子、转录因子和 microRNA。microRNA 是一种小的非编码 RNA，在调节 DC 介导的生理和病理过程中发挥着关键作用。miRNA 失调会影响许多炎症性疾病。本综述的目的是强调 miRNA 在生理和病理条件下由 DC 介导的炎症过程中的重要性，并突出它们在未来治疗中的潜在应用。
