The Healing Foundation Centre, Faculty of Life Sciences, The University of Manchester, Manchester, UK.
Exp Dermatol. 2012 Aug;21(8):581-5. doi: 10.1111/j.1600-0625.2012.01540.x.
Current understanding of the complex process of wound repair is based on decades of study. Integral to this understanding has been the use of in vitro and in vivo models to uncover the key molecular players. Now that major wound processes are more fully understood, therapeutic strategies can be developed to manipulate wound repair. Particularly important areas for future research include developing therapies to aid treatment of healing pathologies such as chronic wounds, and manipulating the normal healing processes to drive a more regenerative phenotype in adults. Here, we discuss the benefits and limitations of current animal-based models and highlight the urgent need for improved predictive preclinical models for wound healing research. We conclude by suggesting directions where more robust models of chronic wound pathologies may arise, expediting the development of novel therapies.
目前对伤口修复这一复杂过程的认识是基于几十年来的研究。理解这一过程的关键是使用体外和体内模型来揭示关键的分子参与者。既然主要的伤口过程得到了更充分的理解，就可以开发治疗策略来操纵伤口修复。未来研究特别重要的领域包括开发治疗方法来辅助治疗慢性伤口等愈合病理，以及操纵正常愈合过程，以在成年人中产生更具再生表型的治疗方法。在这里，我们讨论了当前基于动物的模型的优点和局限性，并强调了迫切需要改进用于伤口愈合研究的预测性临床前模型。最后，我们提出了可能出现更稳健的慢性伤口病理模型的方向，从而加速新型治疗方法的开发。
