Hwang Jee-Hyun, Kang Yeonsoo, Park Heui-Jin, Kim Seolyeong, Lee Su-Hyun, Kim Hangun, Nam Sang-Jip, Lim Kyung-Min
College of Pharmacy, Ewha Womans University, Seoul, Republic of Korea.
Biosolution Co, Seoul, Republic of Korea.
J Ginseng Res. 2023 Sep;47(5):654-661. doi: 10.1016/j.jgr.2023.04.003. Epub 2023 Apr 14.
Ginseng has been used as a traditional medicine and functional cosmetic ingredients for many years. Recent studies have focused on the potential biological effects of the ginseng berry and its ingredients. (+)-Syringaresinol (SYR) is enriched in ginseng berry and its beneficial effects on the skin have been recently reported. However, little is known about the its effects on the wound healing process of skin.
Here, we evaluated the skin wound healing effect of (+)-SYR using the human fibroblast Hs68 cell and pig and human skin tissue model. Scratch wound test and hydrogen peroxide (HPO) induce chemical wound model were employed.
(+)-SYR promoted the migration and proliferation of Hs68 cells without significant cytotoxicity at the tested concentrations. Especially, in pig and human skin tissue, HPO-induced chemical wound was recovered almost completely by (+)-SYR. In line with the finding in Hs68, the protein expression levels of TGF-β and PCNA, a proliferation marker were increased, demonstrating the beneficial effects of (+)-SYR on skin wound repair.
Collectively, we demonstrated that (+)-SYR from ginseng berry, can enhance the wound healing effect by accelerating cell proliferation and skin regeneration, suggesting the potential utility of (+)-SYR for skin wound repair.
人参作为传统药物和功能性化妆品成分已使用多年。最近的研究集中在人参浆果及其成分的潜在生物学效应上。（+）-丁香树脂醇（SYR）在人参浆果中含量丰富，最近有报道称其对皮肤有益。然而，关于其对皮肤伤口愈合过程的影响知之甚少。
在此，我们使用人成纤维细胞Hs68细胞以及猪和人皮肤组织模型评估了（+）-SYR对皮肤伤口愈合的作用。采用划痕试验和过氧化氢（HPO）诱导的化学伤口模型。
在测试浓度下，（+）-SYR促进了Hs68细胞的迁移和增殖，且无明显细胞毒性。特别是，在猪和人皮肤组织中，（+）-SYR几乎完全修复了HPO诱导的化学伤口。与在Hs68细胞中的发现一致，增殖标志物TGF-β和PCNA的蛋白表达水平升高，证明了（+）-SYR对皮肤伤口修复的有益作用。
总体而言，我们证明了人参浆果中的（+）-SYR可通过加速细胞增殖和皮肤再生来增强伤口愈合效果，表明（+）-SYR在皮肤伤口修复方面具有潜在应用价值。
