Department of Biochemistry, University of Washington, Seattle, WA 98103-7350, USA.
Cell Res. 2012 Dec;22(12):1621-3. doi: 10.1038/cr.2012.104. Epub 2012 Jul 10.
Proper control of intercellular communication through the Wnt signaling pathway is of critical importance for many aspects of biology, including head formation during vertebrate embryogenesis. A recent Cell paper describes the discovery of a novel protein, TIKI, which controls head size through a surprising new mechanism of Wnt antagonism.
通过 Wnt 信号通路对细胞间通讯进行适当的控制对于生物学的许多方面都至关重要，包括脊椎动物胚胎发生过程中的头部形成。最近的一篇 Cell 论文描述了一种新型蛋白 TIKI 的发现，该蛋白通过一种令人惊讶的 Wnt 拮抗新机制来控制头部大小。
