Török B, Röth E, Tóth I, Deák G
Int Urol Nephrol. 1979;11(3):215-22. doi: 10.1007/BF02081962.
Donor kidneys were preserved in a Collins-4 solution containing periodate in concentrations of 10(-2) and 10(-4) mole/l, respectively, in an attempt to oxidize the carbohydrate components of the antigen-carrying membrane surfaces and thus to influence the rejection phenomena exhibited by the allogeneic kidney. All kidneys were, however, rejected as a result of a hyperacute reaction indicating that periodate did not react with the hydrophobic membrane structures in vivo. Not only did the antigen thus remain unchanged but the vulnerability of other renal structures to the destructive effect of the killer cells also increased as a result of toxic damage.
供体肾脏分别保存在含有浓度为10⁻²和10⁻⁴摩尔/升高碘酸盐的柯林斯-4溶液中，试图氧化携带抗原的膜表面的碳水化合物成分，从而影响同种异体肾脏表现出的排斥现象。然而，所有肾脏均因超急性反应而被排斥，这表明高碘酸盐在体内并未与疏水膜结构发生反应。不仅抗原因此保持不变，而且由于毒性损伤，其他肾脏结构对杀伤细胞破坏作用的易损性也增加了。
