Department of Microbiology, School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, People's Republic of China.
J Virol. 2012 Aug;86(15):8334-5. doi: 10.1128/JVI.01060-12.
Hepatitis E virus (HEV) is a zoonotic pathogen of which several species of animal were reported as reservoirs. Swine stands out as the major reservoir for HEV infection in humans, as suggested by the close genetic relationship of swine and human viruses. In a previous study, we sequenced the complete genome of a human genotype 4 HEV strain (HM439284) that is prevalent in Jiangsu Province, China. Here we report the complete genome of one genotype 4 HEV strain which is prevalent in swine herds in Jiangsu Province. Phylogenetic analysis indicated that the swine HEV strain in the present study has high sequence homology (>92%) with the genotype 4 HEV strains prevalent in the human population of Jiangsu Province. These results suggested that the genotype 4 HEV strain in the present study is involved in cross-species transmission between swine and humans in this area.
戊型肝炎病毒（HEV）是一种人畜共患病病原体，有几种动物被报道为其宿主。猪是人类 HEV 感染的主要宿主，这是由猪和人类病毒的密切遗传关系所提示的。在之前的研究中，我们对中国江苏省流行的一种人类基因型 4 HEV 株（HM439284）进行了全基因组测序。在这里，我们报告了江苏省猪群中流行的一种基因型 4 HEV 株的全基因组序列。系统进化分析表明，本研究中的猪 HEV 株与江苏省人群中流行的基因型 4 HEV 株具有高度的序列同源性（>92%）。这些结果表明，本研究中的基因型 4 HEV 株参与了该地区猪与人之间的跨种传播。
