Kim Dajeong, Park Dongsun, Kyung Jangbeen, Yang Yun-Hui, Choi Ehn-Kyoung, Lee Yoon-Bok, Kim Hyun-Kyu, Hwang Bang Yeon, Kim Yun-Bae
College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
Lab Anim Res. 2012 Jun;28(2):137-40. doi: 10.5625/lar.2012.28.2.137. Epub 2012 Jun 26.
Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in rat carrageenan-air pouch model. Oral administration of HSE (50-200 mg/kg) suppressed carrageenan-induced exudation and albumin leakage, as well as inflammatory cell infiltration at a high dose (200 mg/kg). Intraperitoneal injection of dexamethasone (2 mg/kg) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content without influence on the cell number. HSE lowered tumor-necrosis factor-α (TNF-α) and nitric oxide (NO), as well as prostaglandin E(2) (PGE(2)). Dexamethasone only reduced TNF-α and NO, while indomethacin decreased PGE(2). The results indicate that HSE exhibits anti-inflammatory effects by inhibiting both TNF-α-NO and cyclooxygenase-2-PGE(2) pathways.
在大鼠角叉菜胶气囊模型中研究了鱼腥草超临界提取物（HSE）的抗炎作用。口服给予HSE（50 - 200毫克/千克）可抑制角叉菜胶诱导的渗出和白蛋白渗漏，高剂量（200毫克/千克）时还可抑制炎症细胞浸润。腹腔注射地塞米松（2毫克/千克）仅减少渗出和细胞浸润，而吲哚美辛（2毫克/千克，腹腔注射）可减少渗出液体积和白蛋白含量，但对细胞数量无影响。HSE可降低肿瘤坏死因子-α（TNF-α）、一氧化氮（NO）以及前列腺素E2（PGE2）。地塞米松仅降低TNF-α和NO，而吲哚美辛降低PGE2。结果表明，HSE通过抑制TNF-α-NO和环氧化酶-2-PGE2途径发挥抗炎作用。
