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Can animal data predict human outcome? Problems and pitfalls of translational animal research.

作者信息

Martić-Kehl Marianne I, Schibli Roger, Schubiger P August

出版信息

Eur J Nucl Med Mol Imaging. 2012 Sep;39(9):1492-6. doi: 10.1007/s00259-012-2175-z.

DOI:10.1007/s00259-012-2175-z
PMID:22790876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3411287/
Abstract
摘要

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本文引用的文献

1
Impact of inherent variability and experimental parameters on the reliability of small animal PET data.固有变异性和实验参数对小动物 PET 数据可靠性的影响。
EJNMMI Res. 2012 Jun 9;2(1):26. doi: 10.1186/2191-219X-2-26.
2
Publication bias in reports of animal stroke studies leads to major overstatement of efficacy.动物中风研究报告中的发表偏倚导致疗效的严重夸大。
PLoS Biol. 2010 Mar 30;8(3):e1000344. doi: 10.1371/journal.pbio.1000344.
3
The ongoing tyranny of statistical significance testing in biomedical research.生物医学研究中持续存在的统计显著性检验暴政。
Eur J Epidemiol. 2010 Apr;25(4):225-30. doi: 10.1007/s10654-010-9440-x. Epub 2010 Mar 26.
4
Systematic variation improves reproducibility of animal experiments.系统性变异可提高动物实验的可重复性。
Nat Methods. 2010 Mar;7(3):167-8. doi: 10.1038/nmeth0310-167.
5
Outcome reporting in industry-sponsored trials of gabapentin for off-label use.加巴喷丁用于非标签用途的行业资助试验中的结果报告。
N Engl J Med. 2009 Nov 12;361(20):1963-71. doi: 10.1056/NEJMsa0906126.
6
Environmental standardization: cure or cause of poor reproducibility in animal experiments?环境标准化：动物实验中重现性差的解决之道还是成因？
Nat Methods. 2009 Apr;6(4):257-61. doi: 10.1038/nmeth.1312.
7
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis.用强效肿瘤血管生成抑制剂进行短期治疗后转移加速。
Cancer Cell. 2009 Mar 3;15(3):232-9. doi: 10.1016/j.ccr.2009.01.021.
8
Medical progress depends on animal models - doesn't it?医学进步依赖于动物模型——难道不是吗？
J R Soc Med. 2008 Feb;101(2):95-8. doi: 10.1258/jrsm.2007.070164.
9
Animal experiments scrutinised: systematic reviews demonstrate poor human clinical and toxicological utility.动物实验审查：系统评价表明其在人体临床和毒理学方面的效用不佳。
ALTEX. 2007;24(4):320-5. doi: 10.14573/altex.2007.4.320.
10
Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach.实验性中风研究设计中偏倚的实证证据：一种元流行病学方法。
Stroke. 2008 Mar;39(3):929-34. doi: 10.1161/STROKEAHA.107.498725. Epub 2008 Jan 31.