Can animal data predict human outcome? Problems and pitfalls of translational animal research.
作者信息
Martić-Kehl Marianne I, Schibli Roger, Schubiger P August
出版信息
Eur J Nucl Med Mol Imaging. 2012 Sep;39(9):1492-6. doi: 10.1007/s00259-012-2175-z.
Abstract
摘要
相似文献
1
Can animal data predict human outcome? Problems and pitfalls of translational animal research.动物数据能预测人类结果吗？转化性动物研究的问题与陷阱。
Eur J Nucl Med Mol Imaging. 2012 Sep;39(9):1492-6. doi: 10.1007/s00259-012-2175-z.
2
Preclinical research: Design animal studies better.临床前研究：更好地设计动物实验。
Nature. 2014 Jun 5;510(7503):35. doi: 10.1038/510035a.
3
Neuroprotective strategies for traumatic brain injury: improving clinical translation.创伤性脑损伤的神经保护策略：改善临床转化。
Int J Mol Sci. 2014 Jan 17;15(1):1216-36. doi: 10.3390/ijms15011216.
4
Policy is political; our ideas about knowledge translation must be too.政策具有政治性；我们对于知识转化的理念也必然如此。
J Epidemiol Community Health. 2014 Nov;68(11):1010-1. doi: 10.1136/jech-2014-203820. Epub 2014 Jun 18.
5
Applying the science of measurement to biology: Why bother?将测量科学应用于生物学：为什么要这样做？
PLoS Biol. 2019 Jun 20;17(6):e3000338. doi: 10.1371/journal.pbio.3000338. eCollection 2019 Jun.
6
Common data elements for preclinical epilepsy research: Standards for data collection and reporting. A TASK3 report of the AES/ILAE Translational Task Force of the ILAE.临床前癫痫研究的通用数据元素：数据收集与报告标准。国际抗癫痫联盟（ILAE）AES/ILAE转化任务组的TASK3报告
Epilepsia. 2017 Nov;58 Suppl 4(Suppl 4):78-86. doi: 10.1111/epi.13906.
7
Improving the screening and treatment of hypertension in people living with HIV: An evidence-based policy brief by Malawi's Knowledge Translation Platform.改善艾滋病毒感染者的高血压筛查与治疗：马拉维知识转化平台的一份循证政策简报
Malawi Med J. 2017 Jun;29(2):224-228. doi: 10.4314/mmj.v29i2.27.
8
Systematic reviews of preclinical animal studies can make significant contributions to health care and more transparent translational medicine.对临床前动物研究的系统评价可为医疗保健和更具透明度的转化医学做出重大贡献。
Cochrane Database Syst Rev. 2014 Mar 28;2014(3):ED000078. doi: 10.1002/14651858.ED000078.
9
Translational spinal cord injury research: preclinical guidelines and challenges.转化性脊髓损伤研究：临床前指南与挑战
Handb Clin Neurol. 2012;109:411-33. doi: 10.1016/B978-0-444-52137-8.00026-7.
10
Evolving challenges to model human diseases for translational research.为转化研究模拟人类疾病面临的不断演变的挑战。
Cell Tissue Res. 2020 May;380(2):305-311. doi: 10.1007/s00441-019-03134-3. Epub 2020 Mar 4.
引用本文的文献
1
Stem Cells and Organoids: A Paradigm Shift in Preclinical Models Toward Personalized Medicine.干细胞与类器官：临床前模型向个性化医学转变的范例。
Pharmaceuticals (Basel). 2025 Jul 1;18(7):992. doi: 10.3390/ph18070992.
2
Human intestinal enteroids: Nonclinical applications for predicting oral drug disposition, toxicity, and efficacy.人肠道类器官：预测口服药物处置、毒性和疗效的非临床应用。
Pharmacol Ther. 2025 May 19:108879. doi: 10.1016/j.pharmthera.2025.108879.
3
Anti-inflammatory drugs as potential antimicrobial agents: a review.抗炎药物作为潜在抗菌剂的综述
Front Pharmacol. 2025 Apr 8;16:1557333. doi: 10.3389/fphar.2025.1557333. eCollection 2025.
4
An Evaluation Benchmark for Adverse Drug Event Prediction from Clinical Trial Results.基于临床试验结果的药物不良事件预测评估基准
Sci Data. 2025 Mar 11;12(1):424. doi: 10.1038/s41597-025-04718-1.
5
Augmenting small biomedical datasets using generative AI methods based on self-organizing neural networks.基于自组织神经网络的生成式人工智能方法增强小型生物医学数据集。
Brief Bioinform. 2024 Nov 22;26(1). doi: 10.1093/bib/bbae640.
6
Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis.大麻二酚与β-石竹烯联合通过AMPK/sirT3/Nrf2轴抑制NLRP3炎性小体/NFκB减轻糖尿病性神经病变
Biomedicines. 2024 Jun 28;12(7):1442. doi: 10.3390/biomedicines12071442.
7
Single high-dose intravenous injection of Wharton's jelly-derived mesenchymal stem cell exerts protective effects in a rat model of metabolic syndrome.单次大剂量静脉注射牙髓间充质干细胞在代谢综合征大鼠模型中发挥保护作用。
Stem Cell Res Ther. 2024 Jun 5;15(1):160. doi: 10.1186/s13287-024-03769-2.
8
Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures.使用人源肝球体共培养物研究肠外营养相关性肝毒性。
Arch Toxicol. 2024 Sep;98(9):3109-3126. doi: 10.1007/s00204-024-03773-8. Epub 2024 May 14.
9
Alveolar Type 2 Epithelial Cell Organoids: Focus on Culture Methods.肺泡II型上皮细胞类器官：聚焦培养方法
Biomedicines. 2023 Nov 12;11(11):3034. doi: 10.3390/biomedicines11113034.
10
A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine.一种完全 3D 打印的多功能肿瘤芯片，可用于多种药物筛选，并与个性化医疗的临床结果相关联。
Commun Biol. 2023 Nov 13;6(1):1157. doi: 10.1038/s42003-023-05531-5.
本文引用的文献
1
Impact of inherent variability and experimental parameters on the reliability of small animal PET data.固有变异性和实验参数对小动物 PET 数据可靠性的影响。
EJNMMI Res. 2012 Jun 9;2(1):26. doi: 10.1186/2191-219X-2-26.
2
Publication bias in reports of animal stroke studies leads to major overstatement of efficacy.动物中风研究报告中的发表偏倚导致疗效的严重夸大。
PLoS Biol. 2010 Mar 30;8(3):e1000344. doi: 10.1371/journal.pbio.1000344.
3
The ongoing tyranny of statistical significance testing in biomedical research.生物医学研究中持续存在的统计显著性检验暴政。
Eur J Epidemiol. 2010 Apr;25(4):225-30. doi: 10.1007/s10654-010-9440-x. Epub 2010 Mar 26.
4
Systematic variation improves reproducibility of animal experiments.系统性变异可提高动物实验的可重复性。
Nat Methods. 2010 Mar;7(3):167-8. doi: 10.1038/nmeth0310-167.
5
Outcome reporting in industry-sponsored trials of gabapentin for off-label use.加巴喷丁用于非标签用途的行业资助试验中的结果报告。
N Engl J Med. 2009 Nov 12;361(20):1963-71. doi: 10.1056/NEJMsa0906126.
6
Environmental standardization: cure or cause of poor reproducibility in animal experiments?环境标准化：动物实验中重现性差的解决之道还是成因？
Nat Methods. 2009 Apr;6(4):257-61. doi: 10.1038/nmeth.1312.
7
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis.用强效肿瘤血管生成抑制剂进行短期治疗后转移加速。
Cancer Cell. 2009 Mar 3;15(3):232-9. doi: 10.1016/j.ccr.2009.01.021.
8
Medical progress depends on animal models - doesn't it?医学进步依赖于动物模型——难道不是吗？
J R Soc Med. 2008 Feb;101(2):95-8. doi: 10.1258/jrsm.2007.070164.
9
Animal experiments scrutinised: systematic reviews demonstrate poor human clinical and toxicological utility.动物实验审查：系统评价表明其在人体临床和毒理学方面的效用不佳。
ALTEX. 2007;24(4):320-5. doi: 10.14573/altex.2007.4.320.
10
Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach.实验性中风研究设计中偏倚的实证证据：一种元流行病学方法。
Stroke. 2008 Mar;39(3):929-34. doi: 10.1161/STROKEAHA.107.498725. Epub 2008 Jan 31.
Zotero 插件