Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China.
J Biomed Mater Res A. 2012 Dec;100(12):3422-7. doi: 10.1002/jbm.a.34268. Epub 2012 Jul 13.
Porous titanium was modified by anodic oxidation and heat treatment method. Scanning electron microscopy and X-ray diffraction examinations revealed that the modified surface of porous titanium was covered by anatase nanotubes. In vitro, the bioactivity of specimens before and after modification was evaluated by immersing into the double-concentration simulated body fluid for 7 days. The porous titanium specimens were implanted into the femurs of dogs for 3 months. The osteointegration of the implants was investigated by push-out test and histological examination. The results showed that the porous titanium with anatase nanotubes has the superior ability of apatite formation and a higher push-out force when compared with the other implants. The histological analysis indicated that the implant with anatase nanotubes had excellent ability to facilitate the osteointegration in vivo.
多孔钛通过阳极氧化和热处理方法进行改性。扫描电子显微镜和 X 射线衍射检查表明，多孔钛的改性表面覆盖有锐钛矿纳米管。在体外，通过将标本在双浓度模拟体液中浸泡 7 天来评估改性前后的生物活性。将多孔钛标本植入犬的股骨中 3 个月。通过推出试验和组织学检查研究植入物的骨整合。结果表明，与其他植入物相比，具有锐钛矿纳米管的多孔钛具有更好的形成磷灰石的能力和更高的推出力。组织学分析表明，具有锐钛矿纳米管的植入物具有促进体内骨整合的优异能力。
