阿尔茨海默病的淀粉样蛋白成像：氟比拉嗪和匹兹堡化合物-B 正电子发射断层扫描的比较。
Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography.
机构信息
Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
出版信息
J Neurol Neurosurg Psychiatry. 2012 Sep;83(9):923-6. doi: 10.1136/jnnp-2012-302548. Epub 2012 Jul 11.
Abstract
BACKGROUND
Amyloid imaging provides in vivo detection of the fibrillar amyloid-β (Aβ) plaques of Alzheimer's disease (AD). The positron emission tomography (PET) ligand, Pittsburgh Compound-B (PiB-C11), is the most well studied amyloid imaging agent, but the short half-life of carbon-11 limits its clinical viability. Florbetapir-F18 recently demonstrated in vivo correlation with postmortem Aβ histopathology, but has not been directly compared with PiB-C11.
METHODS
Fourteen cognitively normal adults and 12 AD patients underwent PiB-C11 and florbetapir-F18 PET scans within a 28-day period.
RESULTS
Both ligands displayed highly significant group discrimination and correlation of regional uptake.
CONCLUSION
These data support the hypothesis that florbetapir-F18 provides comparable information with PiB-C11.
摘要
背景
淀粉样蛋白成像可在体内检测阿尔茨海默病（AD）的纤维状淀粉样-β（Aβ）斑块。正电子发射断层扫描（PET）配体，匹兹堡化合物-B（PiB-C11）是研究最广泛的淀粉样蛋白成像剂，但碳-11 的半衰期短限制了其临床可行性。氟维司群 F18 最近在体内与死后 Aβ 组织病理学显示出相关性，但尚未与 PiB-C11 直接比较。
方法
14 名认知正常的成年人和 12 名 AD 患者在 28 天内接受 PiB-C11 和氟维司群 F18 PET 扫描。
结果
两种配体均显示出高度显著的组间区分和区域摄取的相关性。
结论
这些数据支持氟维司群 F18 可提供与 PiB-C11 相当的信息的假设。
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