Trna Jan, Dítĕ Petr, Adamcová Arona, Crawford Brianna J, Hermanová Markéta
Department of Internal Medicine and Gastroenterology, University Hospital and Faculty of Medicine, Masaryk University Brno, Jihlavska 20 62500 Brno, Czech Republic.
Exp Diabetes Res. 2012;2012:414893. doi: 10.1155/2012/414893. Epub 2012 Jun 27.
The prevalence of diabetes mellitus in pancreatic cancer patients and control subjects was compared.
Retrospective evaluation of 182 pancreatic cancer patients and 135 controls. The presence of diabetes was evaluated and the time period between the diagnosis of diabetes and pancreatic cancer was assessed. A subanalysis based on patient sex was conducted.
Diabetes mellitus was present in 64 patients (35.2%) in pancreatic cancer group and in 27 patients (20.0%) in control group (χ(2) = 8.709; P = 0.003). In 18 patients (28.1% of diabetic pancreatic cancer patients) diabetes was new-onset. Diabetes was new-onset in 23.3% of females compared to 38.1% of males (χ(2) = 1.537; P = 0.215). The overall prevalence of diabetes was significantly higher among female pancreatic cancer patients (25% versus 43.9%; χ(2) = 7.070, P = 0.008), while diabetes prevalence was equally represented in the control group patients (22.1% versus 17.2%; χ(2) = 0.484, P = 0.487).
The prevalence of diabetes mellitus in study group of pancreatic cancer patients was significantly higher when compared to control group. Pancreatic cancer patients with diabetes were predominantly females, while diabetes was equally prevalent among sexes in the control group. Therefore, patient sex may play important role in the risk stratification.
比较胰腺癌患者和对照受试者中糖尿病的患病率。
对182例胰腺癌患者和135例对照进行回顾性评估。评估糖尿病的存在情况，并评估糖尿病诊断与胰腺癌诊断之间的时间间隔。基于患者性别进行亚分析。
胰腺癌组64例患者（35.2%）患有糖尿病，对照组27例患者（20.0%）患有糖尿病（χ² = 8.709；P = 0.003）。18例患者（占糖尿病胰腺癌患者的28.1%）为新发糖尿病。女性新发糖尿病的比例为23.3%，男性为38.1%（χ² = 1.537；P = 0.215）。女性胰腺癌患者中糖尿病的总体患病率显著更高（25%对43.9%；χ² = 7.070，P = 0.008），而对照组患者中糖尿病患病率相当（22.1%对17.2%；χ² = 0.484，P = 0.487）。
与对照组相比，胰腺癌患者研究组中糖尿病的患病率显著更高。患有糖尿病的胰腺癌患者以女性为主，而对照组中糖尿病在两性中的患病率相当。因此，患者性别可能在风险分层中起重要作用。
