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局部应用生药的抗炎成分。IV. 巴拉圭生药“alhucema”（阔叶薰衣草）的成分及抗炎作用

Anti-inflammatory constituents of topically applied crude drugs. IV. Constituents and anti-inflammatory effect of Paraguayan crude drug "alhucema" (Lavandula latifolia Vill.).

作者信息

Shimizu M, Shogawa H, Matsuzawa T, Yonezawa S, Hayashi T, Arisawa M, Suzuki S, Yoshizaki M, Morita N, Ferro E

机构信息

Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1990 Aug;38(8):2283-4. doi: 10.1248/cpb.38.2283.

DOI:10.1248/cpb.38.2283
PMID:2279292
Abstract

The anti-inflammatory active fraction of the Paraguayan crude drug, "Alhucema," Lavandula latifolia Vill. afforded four compounds: coumarin (1), 7-methoxycoumarin (2), trans-phytol (3) and caryophyllene oxide (4). 1 showed a weakly inhibitory effect on carrageenin-induced paw edema in rats on topical application and 4 showed an inhibitory effect on histamine-induced contraction in guinea pig ileum.

摘要

巴拉圭生药“Alhucema”（宽叶薰衣草）的抗炎活性部位分离得到四种化合物：香豆素（1）、7-甲氧基香豆素（2）、反式叶绿醇（3）和氧化石竹烯（4）。化合物1局部应用时对角叉菜胶诱导的大鼠足爪肿胀显示出微弱的抑制作用，化合物4对组胺诱导的豚鼠回肠收缩显示出抑制作用。

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