Haydarpasa Numune Education and Research Hospital, Ophthalmology Clinic, Istanbul, Turkey.
Ocul Immunol Inflamm. 2012 Oct;20(5):349-53. doi: 10.3109/09273948.2012.701701. Epub 2012 Jul 13.
This study aimed to investigate the biomechanical changes in cornea in patients with recurrent anterior uveitis in comparison to healthy controls.
Eighty-five eyes in 51 patients with inactive recurrent anterior uveitis (25 male, 26 female) and 34 eyes of 34 age-matched control subjects (16 male, 18 female) were included. The following measurements were done and compared between patients and controls: corneal hysteresis, corneal response factor, intraocular pressure, and central corneal thickness.
Patients had significantly lower mean corneal hysteresis (8.57 ± 1.60 versus 10.91 ± 1.41, p = .001) and corneal resistance factor (9.24 ± 1.68 versus 11.56 ± 1.46, p = .001) when compared to controls. Among patients, corneal hysteresis and corneal resistance factor did not correlate with duration of the disease or number of attacks per year.
Anterior uveitis seems to be associated with impaired biomechanical strength of the cornea, although no correlations with the duration of illness or attack frequency could be determined.
本研究旨在比较复发性前葡萄膜炎患者与健康对照者的角膜生物力学变化。
纳入 51 例（25 名男性，26 名女性）无活动性复发性前葡萄膜炎患者的 85 只眼和 34 名（16 名男性，18 名女性）年龄匹配的健康对照者的 34 只眼。比较患者和对照组的以下测量值：角膜滞后、角膜阻力因子、眼压和中央角膜厚度。
与对照组相比，患者的平均角膜滞后（8.57±1.60 比 10.91±1.41，p=.001）和角膜阻力因子（9.24±1.68 比 11.56±1.46，p=.001）明显较低。在患者中，角膜滞后和角膜阻力因子与疾病持续时间或每年发作次数均无相关性。
尽管未能确定与疾病持续时间或发作频率的相关性，但前葡萄膜炎似乎与角膜生物力学强度受损有关。
