Medinat srl Clinic, Via Fazioli 22, 60021 Camerano, Italy.
Eur J Pharmacol. 2012 Sep 15;691(1-3):156-62. doi: 10.1016/j.ejphar.2012.07.010. Epub 2012 Jul 13.
Coronary artery disease (CAD) is the most common cause of sudden death, and death of people over 20 years of age. Because ozone therapy can activate the antioxidant system and improve blood circulation and oxygen delivery to tissue, the aim of this study was to investigate the therapeutic efficacy of ozone in patients with CAD, treated with antithrombotic therapy, Aspirin and policosanol. A randomized controlled clinical trial was performed with 53 patients divided into two groups: one (n=27) treated with antithrombotic therapy and other (n=26) treated with antithrombotic therapy plus rectal insufflation of O(3). A parallel group (n=50) age and gender matched was used as reference for the experimental variables. The efficacy of the treatments was evaluated by comparing hemostatic indexes and biochemical markers of oxidative stress in both groups after 20 day of treatment. Ozone treatment significantly (P<0.001) improved prothrombin time when compared to the antithrombotic therapy only group, without modifying bleeding time. Combination antithrombotic therapy+O(3) improved the antioxidant status of patients reducing biomarkers of protein and lipid oxidation, enhancing total antioxidant status and modulating the level of superoxide dismutase and catalase with a 57% and 32% reduction in superoxide dismutase and catalase activities respectively, moving the redox environment to a status of low production of O(2)(•-) with an increase in H(2)O(2) detoxification. No side effects were observed. These results show that medical ozone treatment could be a complementary therapy in the treatment of CAD and its complications.
冠状动脉疾病（CAD）是导致 20 岁以上人群猝死和死亡的最常见原因。由于臭氧疗法可以激活抗氧化系统，改善血液循环和组织供氧，因此本研究旨在探讨臭氧治疗对接受抗血栓治疗、阿司匹林和多廿烷醇治疗的 CAD 患者的治疗效果。本研究进行了一项随机对照临床试验，共纳入 53 例患者，分为两组：一组（n=27）接受抗血栓治疗，另一组（n=26）接受抗血栓治疗加直肠内臭氧输注。将年龄和性别匹配的平行组（n=50）作为实验变量的参考。在治疗 20 天后，通过比较两组的止血指标和氧化应激生化标志物来评估治疗效果。与仅接受抗血栓治疗的组相比，臭氧治疗显著（P<0.001）改善了凝血酶原时间，而不改变出血时间。联合抗血栓治疗+O（3）改善了患者的抗氧化状态，降低了蛋白质和脂质氧化的生物标志物，增强了总抗氧化状态，并调节超氧化物歧化酶和过氧化氢酶的水平，使超氧化物歧化酶和过氧化氢酶的活性分别降低了 57%和 32%，使氧化还原环境向低氧自由基（O2（•-））产生状态转变，同时增加了 H2O2 的解毒。未观察到不良反应。这些结果表明，医用臭氧治疗可能是 CAD 及其并发症治疗的一种补充疗法。
