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低剂量 16 排和 64 排多层螺旋 CT 对肺结节容积测量的敏感性和准确性：人体模体研究。

Sensitivity and accuracy of volumetry of pulmonary nodules on low-dose 16- and 64-row multi-detector CT: an anthropomorphic phantom study.

机构信息

Department of Radiology, University of Groningen, University Medical Center Groningen, EB44, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands.

出版信息

Eur Radiol. 2013 Jan;23(1):139-47. doi: 10.1007/s00330-012-2570-7. Epub 2012 Jul 14.

DOI:10.1007/s00330-012-2570-7
PMID:22797957
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3517707/
Abstract

OBJECTIVE

To assess the sensitivity of detection and accuracy of volumetry by manual and semi-automated quantification of artificial pulmonary nodules in an anthropomorphic thoracic phantom on low-dose CT.

METHODS

Fifteen artificial spherical nodules (diameter 3, 5, 8, 10 and 12 mm; CT densities -800, -630 and +100 HU) were randomly placed inside an anthropomorphic thoracic phantom. The phantom was examined on 16- and 64-row multidetector CT with a low-dose protocol. Two independent blinded observers screened for pulmonary nodules. Nodule diameter was measured manually, and volume calculated. For solid nodules (+100 HU), diameter and volume were also evaluated by semi-automated software. Differences in observed volumes between the manual and semi-automated method were evaluated by a t-test.

RESULTS

Sensitivity was 100 % for all nodules of >5 mm and larger, 60-80 % for solid and 0-20 % for non-solid 3-mm nodules. No false-positive nodules but high inter-observer reliability and inter-technique correlation were found. Volume was underestimated manually by 24.1 ± 14.0 % for nodules of any density, and 26.4 ± 15.5 % for solid nodules, compared with 7.6 ± 8.5 % (P < 0.01) semi-automatically.

CONCLUSION

In an anthropomorphic phantom study, the sensitivity of detection is 100 % for nodules of >5 mm in diameter. Semi-automated volumetry yielded more accurate nodule volumes than manual measurements.

摘要

目的

评估在低剂量 CT 上对人工肺结节进行手动和半自动量化时检测的灵敏度和准确性。

方法

在人工胸部体模内随机放置 15 个人工球形结节（直径 3、5、8、10 和 12mm；CT 密度-800、-630 和+100HU）。体模用 16 排和 64 排多层 CT 进行低剂量检查。两名独立的盲法观察者对肺结节进行筛查。手动测量结节直径，并计算体积。对于实性结节（+100HU），直径和体积也通过半自动软件进行评估。手动和半自动方法之间观察到的体积差异通过 t 检验进行评估。

结果

所有 >5mm 的结节和更大的结节的敏感性均为 100%，实性结节的敏感性为 60-80%，非实性 3mm 结节的敏感性为 0-20%。未发现假阳性结节，但观察者间的可靠性和技术间的相关性较高。与半自动方法相比，手动方法低估了任何密度结节的体积 24.1±14.0%，低估了实性结节的体积 26.4±15.5%（P<0.01）。

结论

在人工体模研究中，直径 >5mm 的结节的检测灵敏度为 100%。半自动体积测量比手动测量更准确地获得结节体积。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd0/3517707/f3404b234dbd/330_2012_2570_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd0/3517707/f52ae194b9d1/330_2012_2570_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd0/3517707/9c26becd6e02/330_2012_2570_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd0/3517707/b25f8691f6cc/330_2012_2570_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd0/3517707/23833be4e9f0/330_2012_2570_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd0/3517707/4af7010853ad/330_2012_2570_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd0/3517707/1d5ddcd1c543/330_2012_2570_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd0/3517707/f3404b234dbd/330_2012_2570_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd0/3517707/f52ae194b9d1/330_2012_2570_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd0/3517707/9c26becd6e02/330_2012_2570_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd0/3517707/b25f8691f6cc/330_2012_2570_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd0/3517707/23833be4e9f0/330_2012_2570_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd0/3517707/4af7010853ad/330_2012_2570_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd0/3517707/1d5ddcd1c543/330_2012_2570_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbd0/3517707/f3404b234dbd/330_2012_2570_Fig7_HTML.jpg

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