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Complement activation and cardiac surgery: a novel target for improving outcomes.补体激活与心脏手术：改善预后的新靶点。
Anesth Analg. 2012 Oct;115(4):759-71. doi: 10.1213/ANE.0b013e3182652b7d. Epub 2012 Jul 13.
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Pexelizumab and its role in the treatment of myocardial infarction and in coronary artery bypass graft surgery: a review.培昔利珠单抗及其在心肌梗死治疗和冠状动脉旁路移植手术中的作用：综述
Recent Pat Cardiovasc Drug Discov. 2008 Jun;3(2):145-52. doi: 10.2174/157489008784705322.
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Controlling the complement system in inflammation.控制炎症中的补体系统。
Immunopharmacology. 1997 Dec;38(1-2):51-62. doi: 10.1016/s0162-3109(97)00057-x.
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Applying complement therapeutics to rare diseases.将补体疗法应用于罕见病。
Clin Immunol. 2015 Dec;161(2):225-40. doi: 10.1016/j.clim.2015.08.009. Epub 2015 Sep 1.
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Therapeutic potential of complement modulation.补体调节的治疗潜力。
Nat Rev Drug Discov. 2010 Jan;9(1):43-56. doi: 10.1038/nrd3011. Epub 2009 Dec 4.
6
Activation of the lectin pathway of complement by cardiopulmonary bypass contributes to the development of systemic inflammatory response syndrome after paediatric cardiac surgery.体外循环激活补体凝集素途径促成小儿心脏手术后全身炎症反应综合征的发生。
Clin Exp Immunol. 2016 May;184(2):257-63. doi: 10.1111/cei.12763. Epub 2016 Feb 8.
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C1 esterase inhibitor in pediatric cardiac surgery with cardiopulmonary bypass plays a vital role in activation of the complement system.在小儿体外循环心脏手术中，C1酯酶抑制剂在补体系统激活过程中起着至关重要的作用。
Heart Vessels. 2020 Jan;35(1):46-51. doi: 10.1007/s00380-019-01466-2. Epub 2019 Jul 5.
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Impact of pexelizumab, an anti-C5 complement antibody, on total mortality and adverse cardiovascular outcomes in cardiac surgical patients undergoing cardiopulmonary bypass.抗C5补体抗体培塞利珠单抗对接受体外循环心脏手术患者的总死亡率和不良心血管结局的影响。
Ann Thorac Surg. 2004 Mar;77(3):942-9; discussion 949-50. doi: 10.1016/j.athoracsur.2003.08.054.
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The possible role of complement activation in Alzheimer disease.
Trends Mol Med. 2002 Nov;8(11):519-23. doi: 10.1016/s1471-4914(02)02422-x.
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Therapeutic complement inhibition: new developments.治疗性补体抑制：新进展。
Semin Thromb Hemost. 2010 Sep;36(6):660-8. doi: 10.1055/s-0030-1262888. Epub 2010 Sep 23.
引用本文的文献
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Vasoplegic Syndrome Following Bypass: A Comprehensive Review of Pathophysiology and Proposed Treatments.体外循环后血管麻痹综合征：病理生理学及治疗建议的综合综述
Cureus. 2025 Jan 27;17(1):e78057. doi: 10.7759/cureus.78057. eCollection 2025 Jan.
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The Crucial Triad: Endothelial Glycocalyx, Oxidative Stress, and Inflammation in Cardiac Surgery-Exploring the Molecular Connections.心脏手术中的关键三联体：内皮糖萼、氧化应激与炎症——探索分子联系
Int J Mol Sci. 2024 Oct 10;25(20):10891. doi: 10.3390/ijms252010891.
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High Preoperative Systemic Immune-Inflammation Index Values Significantly Predicted Poor Outcomes After on-Pump Coronary Artery Bypass Surgery.术前全身免疫炎症指数值高显著预示着体外循环冠状动脉搭桥术后预后不良。
J Inflamm Res. 2024 Feb 7;17:755-764. doi: 10.2147/JIR.S449795. eCollection 2024.
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The Complement System: A Potential Therapeutic Target in Liver Cancer.补体系统：肝癌潜在的治疗靶点
Life (Basel). 2022 Sep 30;12(10):1532. doi: 10.3390/life12101532.
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Narrative review of the systemic inflammatory reaction to cardiac surgery and cardiopulmonary bypass.心脏手术和体外循环中全身炎症反应的叙述性综述。
Artif Organs. 2022 Apr;46(4):568-577. doi: 10.1111/aor.14171. Epub 2022 Jan 21.
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Inflammation in Metabolic and Cardiovascular Disorders-Role of Oxidative Stress.代谢与心血管疾病中的炎症——氧化应激的作用
Life (Basel). 2021 Jul 9;11(7):672. doi: 10.3390/life11070672.
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An Optimized and Standardized Rapid Flow Cytometry Functional Method for Heparin-Induced Thrombocytopenia.一种用于肝素诱导的血小板减少症的优化且标准化的快速流式细胞术功能检测方法。
Biomedicines. 2021 Mar 13;9(3):296. doi: 10.3390/biomedicines9030296.
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Factors involved in initiation and regulation of complement lectin pathway influence postoperative outcome after pediatric cardiac surgery involving cardiopulmonary bypass.补体凝集素途径的启动和调节所涉及的因素影响体外循环小儿心脏手术后的术后结果。
Sci Rep. 2019 Feb 27;9(1):2930. doi: 10.1038/s41598-019-39742-w.
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Bioactive Sphingolipids, Complement Cascade, and Free Hemoglobin Levels in Stable Coronary Artery Disease and Acute Myocardial Infarction.稳定型冠状动脉疾病和急性心肌梗死中的生物活性神经酰胺、补体级联和游离血红蛋白水平。
Mediators Inflamm. 2018 Jul 9;2018:2691934. doi: 10.1155/2018/2691934. eCollection 2018.
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Activation of complement factor B contributes to murine and human myocardial ischemia/reperfusion injury.补体因子B的激活会导致小鼠和人类心肌缺血/再灌注损伤。
PLoS One. 2017 Jun 29;12(6):e0179450. doi: 10.1371/journal.pone.0179450. eCollection 2017.
本文引用的文献
1
Pathophysiology of hereditary angioedema.遗传性血管性水肿的病理生理学。
Am J Rhinol Allergy. 2011 Nov-Dec;25(6):373-8. doi: 10.2500/ajra.2011.25.3661.
2
MASP-2 activation is involved in ischemia-related necrotic myocardial injury in humans.MASP-2 的激活与人类缺血相关的坏死性心肌损伤有关。
Int J Cardiol. 2013 Jun 20;166(2):499-504. doi: 10.1016/j.ijcard.2011.11.032. Epub 2011 Dec 15.
3
Mannose-binding lectin-associated serine protease-1 is a significant contributor to coagulation in a murine model of occlusive thrombosis.甘露糖结合凝集素相关丝氨酸蛋白酶-1 是闭塞性血栓形成小鼠模型中凝血的重要贡献者。
J Immunol. 2012 Jan 15;188(2):885-91. doi: 10.4049/jimmunol.1102916. Epub 2011 Dec 12.
4
Absence of mannose-binding lectin prevents hyperglycemic cardiovascular complications.甘露糖结合凝集素缺失可预防高血糖性心血管并发症。
Am J Pathol. 2012 Jan;180(1):104-12. doi: 10.1016/j.ajpath.2011.09.026. Epub 2011 Nov 8.
5
The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway.甘露糖结合凝集素相关丝氨酸蛋白酶-3 在替代补体途径激活中的作用。
J Immunol. 2011 Oct 1;187(7):3751-8. doi: 10.4049/jimmunol.1100280. Epub 2011 Aug 24.
6
Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury.靶向甘露聚糖结合凝集素相关丝氨酸蛋白酶-2 可预防心肌和胃肠道缺血/再灌注损伤。
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7523-8. doi: 10.1073/pnas.1101748108. Epub 2011 Apr 18.
7
Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity.收集素 11（CL-11，CL-K1）是一种与 MASP-1/3 相关的血浆收集素，具有微生物结合活性。
J Immunol. 2010 Nov 15;185(10):6096-104. doi: 10.4049/jimmunol.1002185. Epub 2010 Oct 18.
8
Effects of C5 complement inhibitor pexelizumab on outcome in high-risk coronary artery bypass grafting: combined results from the PRIMO-CABG I and II trials.C5 补体抑制剂 pexelizumab 对高危冠状动脉旁路移植术结局的影响：PRIMO-CABG I 和 II 试验的联合结果。
J Thorac Cardiovasc Surg. 2011 Jul;142(1):89-98. doi: 10.1016/j.jtcvs.2010.08.035. Epub 2010 Sep 28.
9
Molecular intercommunication between the complement and coagulation systems.补体系统与凝血系统的分子相互通讯。
J Immunol. 2010 Nov 1;185(9):5628-36. doi: 10.4049/jimmunol.0903678. Epub 2010 Sep 24.
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Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation.甘露糖结合凝集素及其相关蛋白酶（MASPs）介导凝血，其缺乏是感染相关并发症（包括弥散性血管内凝血）发展的危险因素。
Immunobiology. 2011 Jan-Feb;216(1-2):96-102. doi: 10.1016/j.imbio.2010.02.005. Epub 2010 Mar 4.
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