补体激活与心脏手术：改善预后的新靶点。
Complement activation and cardiac surgery: a novel target for improving outcomes.
机构信息
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Anesth Analg. 2012 Oct;115(4):759-71. doi: 10.1213/ANE.0b013e3182652b7d. Epub 2012 Jul 13.
Abstract
Complement activation and the resulting inflammatory response is an important potential mechanism for multisystem organ injury in cardiac surgery. Novel therapeutic strategies using complement inhibitors may hold promise for improving outcomes for cardiac surgical patients by attenuating complement activation or its biologically active effector molecules. Recent clinical trials evaluating complement inhibitors have provided important data to further delineate the impact of complement activation and its inhibition on clinical outcomes. In this review we examine the role of complement activation and its inhibition as a therapeutic approach in cardiac surgery.
摘要
补体激活及其引发的炎症反应是心脏手术多器官损伤的一个重要潜在机制。使用补体抑制剂的新型治疗策略通过减弱补体激活或其生物活性效应分子，可能为改善心脏手术患者的预后带来希望。最近评估补体抑制剂的临床试验提供了重要数据，进一步阐明了补体激活及其抑制对临床结局的影响。在这篇综述中，我们探讨了补体激活及其抑制作为心脏手术治疗方法的作用。
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