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对硅酮注射的肉芽肿反应。

Granulomatous reaction to silicone injection.

作者信息

Ellis Lixia Z, Cohen Joel L, High Whitney

出版信息

J Clin Aesthet Dermatol. 2012 Jul;5(7):44-7.

PMID:22798975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3396457/
Abstract

The use of liquid injectable silicone for soft tissue augmentation is controversial. Proponents of its use consider it safe when highly purified medical-grade product is employed appropriately by well-trained and experienced physicians, whereas opponents believe complications from silicone injections are inherently inevitable and unpredictable and that they outweigh the benefits. One of the feared complications is granuloma formation. In this article, the authors report two cases of granulomatous nodules from silicone injections and present the histological features. These cases highlight the need for continued vigilance among clinicians about this complication and the importance not only of careful selection of filler products, but also of patients knowing the credentials of their injection practitioners.

摘要

使用液体注射用硅胶进行软组织填充存在争议。其支持者认为,当经过高度纯化的医用级产品由训练有素且经验丰富的医生适当地使用时,它是安全的;而反对者则认为,硅胶注射引起的并发症本质上是不可避免且无法预测的,其危害超过了益处。令人担忧的并发症之一是肉芽肿形成。在本文中,作者报告了两例硅胶注射后形成肉芽肿结节的病例,并展示了组织学特征。这些病例凸显了临床医生对此类并发症持续保持警惕的必要性,以及不仅要谨慎选择填充产品,而且患者要了解注射医生资质的重要性。

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本文引用的文献

1
The efficacy of perilesional surgical approach for foreign body granuloma.病灶周围手术入路治疗异物肉芽肿的疗效
Plast Reconstr Surg. 2011 Jun;127(6):121e-123e. doi: 10.1097/PRS.0b013e318213a15c.
2
Delayed onset nodules from liquid injectable silicone: report of a case, evaluation of associated histopathology and results of treatment with minocycline and celocoxib.液态注射用硅酮所致的迟发性结节:1例报告、相关组织病理学评估以及米诺环素和塞来昔布的治疗结果
J Drugs Dermatol. 2009 Oct;8(10):952-4.
3
Silicone migration and granuloma formation.硅胶迁移与肉芽肿形成。
J Cosmet Dermatol. 2009 Jun;8(2):92-7. doi: 10.1111/j.1473-2165.2009.00436.x.
4
Treatment options for dermal filler complications.真皮填充剂并发症的治疗选择。
Aesthet Surg J. 2006 May-Jun;26(3):356-64. doi: 10.1016/j.asj.2006.04.002.
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Foreign body granuloma formation secondary to silicone injection.硅酮注射继发的异物肉芽肿形成
Dermatol Online J. 2008 Jul 15;14(7):20.
6
Carbon dioxide laser vaporization of facial siliconomas: flash in the pan or way of the future?
Ann Plast Surg. 2008 Mar;60(3):272-5. doi: 10.1097/SAP.0b013e318065c4e1.
7
The long-term host response to liquid silicone injected during soft tissue augmentation procedures: a microscopic appraisal.软组织填充手术中注射液态硅酮后的长期宿主反应:微观评估
Dermatol Surg. 2007 Dec;33 Suppl 2:S186-92; discussion S192. doi: 10.1111/j.1524-4725.2007.33359.x.
8
A diagnostic trap for the dermatopathologist: granulomatous reactions from cutaneous microimplants for cosmetic purposes.皮肤病理学家的诊断陷阱:用于美容目的的皮肤微植入物引起的肉芽肿反应。
J Cutan Pathol. 2007 Mar;34(3):281-3. doi: 10.1111/j.1600-0560.2006.00607.x.
9
Management of complications after implantation of fillers.填充剂植入后并发症的处理
J Cosmet Dermatol. 2004 Jan;3(1):2-15. doi: 10.1111/j.1473-2130.2004.00058.x.
10
Etanercept therapy for silicone granuloma.依那西普治疗硅酮肉芽肿
J Drugs Dermatol. 2006 Oct;5(9):894-6.