Panteleev Pavel V, Balandin Sergey V, Ivanov Vadim T, Ovchinnikova Tatiana V
M.M. Shemyakin and Yu.A.Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya str., 16/10, 117997 Moscow, Russian Federation.
M.M.Shemyakin and Yu.A.Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation.
Curr Med Chem. 2017;24(17):1724-1746. doi: 10.2174/0929867324666170424124416.
Endogenous antimicrobial peptides (AMPs) are evolutionary ancient molecular factors of innate immunity that play the key role in host defense. Because of the low resistance rate, AMPs have caught extensive attention as possible alternatives to conventional antibiotics. Over the last years, it has become evident that biological functions of AMPs are beyond direct killing of microbial cells. This review focuses on a relatively small family of animal host defense peptides with the β-hairpin structure stabilized by disulfide bridges. Their small size, rigid structure, stability to proteases, and plethora of biological functions, including antibacterial, antifungal, antiviral, anticancer, endotoxin-binding, metabolism- and immune- modulating activities, make natural β-hairpin AMPs an attractive molecular basis for drug design.
内源性抗菌肽（AMPs）是先天性免疫进化古老的分子因子，在宿主防御中起关键作用。由于耐药率低，抗菌肽作为传统抗生素的可能替代品已引起广泛关注。在过去几年中，已明显看出抗菌肽的生物学功能不仅仅是直接杀死微生物细胞。本综述聚焦于一个相对较小的动物宿主防御肽家族，其具有由二硫键稳定的β-发夹结构。它们体积小、结构刚性、对蛋白酶稳定，以及具有多种生物学功能，包括抗菌、抗真菌、抗病毒、抗癌、内毒素结合、代谢调节和免疫调节活性，使得天然β-发夹抗菌肽成为药物设计有吸引力的分子基础。
