印度果蝠（Pteropus giganteus）中尼帕病毒 RNA 的检测。
Detection of Nipah virus RNA in fruit bat (Pteropus giganteus) from India.
机构信息
Microbial Containment Complex, National Institute of Virology, Pune, India.
出版信息
Am J Trop Med Hyg. 2012 Sep;87(3):576-8. doi: 10.4269/ajtmh.2012.11-0416. Epub 2012 Jul 16.
Abstract
The study deals with the survey of different bat populations (Pteropus giganteus, Cynopterus sphinx, and Megaderma lyra) in India for highly pathogenic Nipah virus (NiV), Reston Ebola virus, and Marburg virus. Bats (n = 140) from two states in India (Maharashtra and West Bengal) were tested for IgG (serum samples) against these viruses and for virus RNAs. Only NiV RNA was detected in a liver homogenate of P. giganteus captured in Myanaguri, West Bengal. Partial sequence analysis of nucleocapsid, glycoprotein, fusion, and phosphoprotein genes showed similarity with the NiV sequences from earlier outbreaks in India. A serum sample of this bat was also positive by enzyme-linked immunosorbent assay for NiV-specific IgG. This is the first report on confirmation of Nipah viral RNA in Pteropus bat from India and suggests the possible role of this species in transmission of NiV in India.
摘要
本研究调查了印度不同蝙蝠种群（大狐蝠、食果蝠和蹄蝠）中高致病性的尼帕病毒（NiV）、雷斯顿埃博拉病毒和马尔堡病毒。从印度两个邦（马哈拉施特拉邦和西孟加拉邦）采集了 140 只蝙蝠（血清样本），对这些病毒的 IgG 进行了检测，并检测了病毒 RNA。在西孟加拉邦的迈拉那加里捕获的大狐蝠的肝匀浆中仅检测到尼帕病毒 RNA。对核衣壳蛋白、糖蛋白、融合蛋白和磷蛋白基因的部分序列分析表明，与印度早期暴发的尼帕病毒序列具有相似性。该蝙蝠的血清样本也通过酶联免疫吸附试验对尼帕病毒特异性 IgG 呈阳性。这是首次在印度大狐蝠中确认尼帕病毒 RNA 的报告，表明该物种可能在印度传播尼帕病毒中发挥作用。
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